GGA2 interacts with EGFR cytoplasmic domain to stabilize the receptor expression and promote cell growth

Abstract Epidermal growth factor receptor (EGFR) signaling and its downregulation upon ligand binding have been extensively documented. However, the mechanisms by which cells maintain steady-state EGFR expression remain poorly understood. Here, we report a novel role of Golgi-localized, γ-adaptin ea...

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Auteurs principaux: Takefumi Uemura, Satoshi Kametaka, Satoshi Waguri
Format: article
Langue:EN
Publié: Nature Portfolio 2018
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Accès en ligne:https://doaj.org/article/dcd67bdd63cd413c9edfbc3b02b1c99f
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