An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques

Atherosclerosis progression is linked to inflammatory processes in the blood vessel wall. Here, the authors show that, with the progression of atherosclerosis, the resolution of inflammation is impaired as the result of an imbalance between specialized pro-resolving lipid mediators and leukotrienes.

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Autores principales:	Gabrielle Fredman, Jason Hellmann, Jonathan D. Proto, George Kuriakose, Romain A. Colas, Bernhard Dorweiler, E. Sander Connolly, Robert Solomon, David M. Jones, Eric J. Heyer, Matthew Spite, Ira Tabas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dd0a0542340e491da02734ce00925f06
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spelling	oai:doaj.org-article:dd0a0542340e491da02734ce00925f062021-12-02T16:57:28ZAn imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques10.1038/ncomms128592041-1723https://doaj.org/article/dd0a0542340e491da02734ce00925f062016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12859https://doaj.org/toc/2041-1723Atherosclerosis progression is linked to inflammatory processes in the blood vessel wall. Here, the authors show that, with the progression of atherosclerosis, the resolution of inflammation is impaired as the result of an imbalance between specialized pro-resolving lipid mediators and leukotrienes.Gabrielle FredmanJason HellmannJonathan D. ProtoGeorge KuriakoseRomain A. ColasBernhard DorweilerE. Sander ConnollyRobert SolomonDavid M. JonesEric J. HeyerMatthew SpiteIra TabasNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gabrielle Fredman Jason Hellmann Jonathan D. Proto George Kuriakose Romain A. Colas Bernhard Dorweiler E. Sander Connolly Robert Solomon David M. Jones Eric J. Heyer Matthew Spite Ira Tabas An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques
description	Atherosclerosis progression is linked to inflammatory processes in the blood vessel wall. Here, the authors show that, with the progression of atherosclerosis, the resolution of inflammation is impaired as the result of an imbalance between specialized pro-resolving lipid mediators and leukotrienes.
format	article
author	Gabrielle Fredman Jason Hellmann Jonathan D. Proto George Kuriakose Romain A. Colas Bernhard Dorweiler E. Sander Connolly Robert Solomon David M. Jones Eric J. Heyer Matthew Spite Ira Tabas
author_facet	Gabrielle Fredman Jason Hellmann Jonathan D. Proto George Kuriakose Romain A. Colas Bernhard Dorweiler E. Sander Connolly Robert Solomon David M. Jones Eric J. Heyer Matthew Spite Ira Tabas
author_sort	Gabrielle Fredman
title	An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques
title_short	An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques
title_full	An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques
title_fullStr	An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques
title_full_unstemmed	An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques
title_sort	imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/dd0a0542340e491da02734ce00925f06
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An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques

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