Promoter G-quadruplexes and transcription factors cooperate to shape the cell type-specific transcriptome

G-quadruplex (G4) structures play complex roles linked to transcription regulation. Here the authors, by comparing G4 location and transcript levels in liposarcoma and keratinocyte cells, reveal that G4s cooperate with transcription factors to determine cell-specific transcriptional programs.

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Autores principales:	Sara Lago, Matteo Nadai, Filippo M. Cernilogar, Maryam Kazerani, Helena Domíniguez Moreno, Gunnar Schotta, Sara N. Richter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dd1811100f074ec8a3558e9cc0a6bb45
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spelling	oai:doaj.org-article:dd1811100f074ec8a3558e9cc0a6bb452021-12-02T17:44:52ZPromoter G-quadruplexes and transcription factors cooperate to shape the cell type-specific transcriptome10.1038/s41467-021-24198-22041-1723https://doaj.org/article/dd1811100f074ec8a3558e9cc0a6bb452021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24198-2https://doaj.org/toc/2041-1723G-quadruplex (G4) structures play complex roles linked to transcription regulation. Here the authors, by comparing G4 location and transcript levels in liposarcoma and keratinocyte cells, reveal that G4s cooperate with transcription factors to determine cell-specific transcriptional programs.Sara LagoMatteo NadaiFilippo M. CernilogarMaryam KazeraniHelena Domíniguez MorenoGunnar SchottaSara N. RichterNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sara Lago Matteo Nadai Filippo M. Cernilogar Maryam Kazerani Helena Domíniguez Moreno Gunnar Schotta Sara N. Richter Promoter G-quadruplexes and transcription factors cooperate to shape the cell type-specific transcriptome
description	G-quadruplex (G4) structures play complex roles linked to transcription regulation. Here the authors, by comparing G4 location and transcript levels in liposarcoma and keratinocyte cells, reveal that G4s cooperate with transcription factors to determine cell-specific transcriptional programs.
format	article
author	Sara Lago Matteo Nadai Filippo M. Cernilogar Maryam Kazerani Helena Domíniguez Moreno Gunnar Schotta Sara N. Richter
author_facet	Sara Lago Matteo Nadai Filippo M. Cernilogar Maryam Kazerani Helena Domíniguez Moreno Gunnar Schotta Sara N. Richter
author_sort	Sara Lago
title	Promoter G-quadruplexes and transcription factors cooperate to shape the cell type-specific transcriptome
title_short	Promoter G-quadruplexes and transcription factors cooperate to shape the cell type-specific transcriptome
title_full	Promoter G-quadruplexes and transcription factors cooperate to shape the cell type-specific transcriptome
title_fullStr	Promoter G-quadruplexes and transcription factors cooperate to shape the cell type-specific transcriptome
title_full_unstemmed	Promoter G-quadruplexes and transcription factors cooperate to shape the cell type-specific transcriptome
title_sort	promoter g-quadruplexes and transcription factors cooperate to shape the cell type-specific transcriptome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dd1811100f074ec8a3558e9cc0a6bb45
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Promoter G-quadruplexes and transcription factors cooperate to shape the cell type-specific transcriptome

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