Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4

MLL3 and MLL4 are members of the SET1/MLL family of histone H3K4 methyltransferases, which are responsible for monomethylating histone H3K4 on enhancers. Here the authors show that an extended PHD domain (ePHD6) in MLL3 and MLL4 specifically recognizes an H4H18-containing fragment of histone H4, and...

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Autores principales: Yanli Liu, Su Qin, Tsai-Yu Chen, Ming Lei, Shilpa S. Dhar, Jolene Caifeng Ho, Aiping Dong, Peter Loppnau, Yanjun Li, Min Gyu Lee, Jinrong Min
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/dd25eb29a56b4175b0c7fc357946f2ae
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