Replacement of Chalcone-Ethers with Chalcone-Thioethers as Potent and Highly Selective Monoamine Oxidase-B Inhibitors and Their Protein-Ligand Interactions

Replacement of Chalcone-Ethers with Chalcone-Thioethers as Potent and Highly Selective Monoamine Oxidase-B Inhibitors and Their Protein-Ligand Interactions

To develop new potent and highly selective MAO-B inhibitors from chalcone-thioethers, eleven chalcones-thioethers were synthesized and their monoamine oxidase (MAO) inhibition, kinetics, reversibility, and cytotoxicity of lead compounds were analyzed. Molecular dynamics were carried out to investiga...

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Autores principales: Bijo Mathew, Jong Min Oh, Ahmed Khames, Mohamed A. Abdelgawad, T. M. Rangarajan, Lekshmi R. Nath, Clement Agoni, Mahmoud E. S. Soliman, Githa Elizabeth Mathew, Hoon Kim
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
chalcone
MAO-B
selectivity
reversibility
cytotoxicity
ROS
Medicine
R
Pharmacy and materia medica
RS1-441
Acceso en línea:https://doaj.org/article/dd6eb7ca415747acbb527b53f6944a97
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https://doaj.org/article/dd6eb7ca415747acbb527b53f6944a97

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