Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia

Cut-like homeobox 1 (CUX1) is a haploinsufficient tumor suppressor commonly inactivated in acute myeloid leukemia and high-risk myelodysplasia. Here, in a genetically modified murine model, the authors show that CUX1 deficiency impairs apoptosis leading to leukemia when combined with mutant Flt3-ITD...

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Autores principales:	Emmanuelle Supper, Saskia Rudat, Vivek Iyer, Alastair Droop, Kim Wong, Jean-François Spinella, Patrick Thomas, Guy Sauvageau, David J. Adams, Chi C. Wong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dda81ff46bb244da8bbf4aca6a147a93
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spelling	oai:doaj.org-article:dda81ff46bb244da8bbf4aca6a147a932021-12-02T16:55:53ZCut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia10.1038/s41467-021-22750-82041-1723https://doaj.org/article/dda81ff46bb244da8bbf4aca6a147a932021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22750-8https://doaj.org/toc/2041-1723Cut-like homeobox 1 (CUX1) is a haploinsufficient tumor suppressor commonly inactivated in acute myeloid leukemia and high-risk myelodysplasia. Here, in a genetically modified murine model, the authors show that CUX1 deficiency impairs apoptosis leading to leukemia when combined with mutant Flt3-ITD.Emmanuelle SupperSaskia RudatVivek IyerAlastair DroopKim WongJean-François SpinellaPatrick ThomasGuy SauvageauDavid J. AdamsChi C. WongNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emmanuelle Supper Saskia Rudat Vivek Iyer Alastair Droop Kim Wong Jean-François Spinella Patrick Thomas Guy Sauvageau David J. Adams Chi C. Wong Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia
description	Cut-like homeobox 1 (CUX1) is a haploinsufficient tumor suppressor commonly inactivated in acute myeloid leukemia and high-risk myelodysplasia. Here, in a genetically modified murine model, the authors show that CUX1 deficiency impairs apoptosis leading to leukemia when combined with mutant Flt3-ITD.
format	article
author	Emmanuelle Supper Saskia Rudat Vivek Iyer Alastair Droop Kim Wong Jean-François Spinella Patrick Thomas Guy Sauvageau David J. Adams Chi C. Wong
author_facet	Emmanuelle Supper Saskia Rudat Vivek Iyer Alastair Droop Kim Wong Jean-François Spinella Patrick Thomas Guy Sauvageau David J. Adams Chi C. Wong
author_sort	Emmanuelle Supper
title	Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia
title_short	Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia
title_full	Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia
title_fullStr	Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia
title_full_unstemmed	Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia
title_sort	cut-like homeobox 1 (cux1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dda81ff46bb244da8bbf4aca6a147a93
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Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia

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