An enzymatic atavist revealed in dual pathways for water activation.
Inosine monophosphate dehydrogenase (IMPDH) catalyzes an essential step in the biosynthesis of guanine nucleotides. This reaction involves two different chemical transformations, an NAD-linked redox reaction and a hydrolase reaction, that utilize mutually exclusive protein conformations with distinc...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | article |
| Langue: | EN |
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Public Library of Science (PLoS)
2008
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| Accès en ligne: | https://doaj.org/article/ddb9bd56b4474bdcb042295fdd6460ad |
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