Spearheading future omics analyses using dyngen, a multi-modal simulator of single cells

To benchmark single cell bioinformatics tools, data simulators can provide a robust ground truth. Here the authors present dyngen, a multi-modal simulator, and apply it to aligning cell developmental trajectories, cell-specific regulatory network inference and estimation of RNA velocity.

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Autores principales:	Robrecht Cannoodt, Wouter Saelens, Louise Deconinck, Yvan Saeys
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ddc181f462d749749bcb5aa8747f29b5
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spelling	oai:doaj.org-article:ddc181f462d749749bcb5aa8747f29b52021-12-02T17:45:00ZSpearheading future omics analyses using dyngen, a multi-modal simulator of single cells10.1038/s41467-021-24152-22041-1723https://doaj.org/article/ddc181f462d749749bcb5aa8747f29b52021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24152-2https://doaj.org/toc/2041-1723To benchmark single cell bioinformatics tools, data simulators can provide a robust ground truth. Here the authors present dyngen, a multi-modal simulator, and apply it to aligning cell developmental trajectories, cell-specific regulatory network inference and estimation of RNA velocity.Robrecht CannoodtWouter SaelensLouise DeconinckYvan SaeysNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Robrecht Cannoodt Wouter Saelens Louise Deconinck Yvan Saeys Spearheading future omics analyses using dyngen, a multi-modal simulator of single cells
description	To benchmark single cell bioinformatics tools, data simulators can provide a robust ground truth. Here the authors present dyngen, a multi-modal simulator, and apply it to aligning cell developmental trajectories, cell-specific regulatory network inference and estimation of RNA velocity.
format	article
author	Robrecht Cannoodt Wouter Saelens Louise Deconinck Yvan Saeys
author_facet	Robrecht Cannoodt Wouter Saelens Louise Deconinck Yvan Saeys
author_sort	Robrecht Cannoodt
title	Spearheading future omics analyses using dyngen, a multi-modal simulator of single cells
title_short	Spearheading future omics analyses using dyngen, a multi-modal simulator of single cells
title_full	Spearheading future omics analyses using dyngen, a multi-modal simulator of single cells
title_fullStr	Spearheading future omics analyses using dyngen, a multi-modal simulator of single cells
title_full_unstemmed	Spearheading future omics analyses using dyngen, a multi-modal simulator of single cells
title_sort	spearheading future omics analyses using dyngen, a multi-modal simulator of single cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ddc181f462d749749bcb5aa8747f29b5
work_keys_str_mv	AT robrechtcannoodt spearheadingfutureomicsanalysesusingdyngenamultimodalsimulatorofsinglecells AT woutersaelens spearheadingfutureomicsanalysesusingdyngenamultimodalsimulatorofsinglecells AT louisedeconinck spearheadingfutureomicsanalysesusingdyngenamultimodalsimulatorofsinglecells AT yvansaeys spearheadingfutureomicsanalysesusingdyngenamultimodalsimulatorofsinglecells
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Spearheading future omics analyses using dyngen, a multi-modal simulator of single cells

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