The Methionine 549 and Leucine 552 Residues of Friedelin Synthase from <i>Maytenus ilicifolia</i> Are Important for Substrate Binding Specificity

Friedelin, a pentacyclic triterpene found in the leaves of the Celastraceae species, demonstrates numerous biological activities and is a precursor of quinonemethide triterpenes, which are promising antitumoral agents. Friedelin is biosynthesized from the cyclization of 2,3-oxidosqualene, involving...

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Autores principales: Bruna F. Mazzeu, Tatiana M. Souza-Moreira, Andrew A. Oliveira, Melissa Remlinger, Lidiane G. Felippe, Sandro R. Valentini, Rafael V. C. Guido, Cleslei F. Zanelli, Maysa Furlan
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
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Acceso en línea:https://doaj.org/article/ddc35de5e5134f5c9b696820b9fe8270
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