Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington’s disease models

Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington’s disease models

Cognitive decline in Huntington’s disease (HD) may be due to impaired hippocampal synaptic plasticity. In this study the authors show that AMPA receptor surface diffusion, a key player in synaptic plasticity, is deregulated in multiple HD mouse models as a result of impaired BDNF signalling that und...

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Autores principales: Hongyu Zhang, Chunlei Zhang, Jean Vincent, Diana Zala, Caroline Benstaali, Matthieu Sainlos, Dolors Grillo-Bosch, Sophie Daburon, Françoise Coussen, Yoon Cho, Denis J. David, Frederic Saudou, Yann Humeau, Daniel Choquet
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/ddde984bb066475ab87f81ec554c5d91
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https://doaj.org/article/ddde984bb066475ab87f81ec554c5d91

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