Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington’s disease models

Cognitive decline in Huntington’s disease (HD) may be due to impaired hippocampal synaptic plasticity. In this study the authors show that AMPA receptor surface diffusion, a key player in synaptic plasticity, is deregulated in multiple HD mouse models as a result of impaired BDNF signalling that und...

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Autores principales:	Hongyu Zhang, Chunlei Zhang, Jean Vincent, Diana Zala, Caroline Benstaali, Matthieu Sainlos, Dolors Grillo-Bosch, Sophie Daburon, Françoise Coussen, Yoon Cho, Denis J. David, Frederic Saudou, Yann Humeau, Daniel Choquet
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ddde984bb066475ab87f81ec554c5d91
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spelling	oai:doaj.org-article:ddde984bb066475ab87f81ec554c5d912021-12-02T16:49:54ZModulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington’s disease models10.1038/s41467-018-06675-32041-1723https://doaj.org/article/ddde984bb066475ab87f81ec554c5d912018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06675-3https://doaj.org/toc/2041-1723Cognitive decline in Huntington’s disease (HD) may be due to impaired hippocampal synaptic plasticity. In this study the authors show that AMPA receptor surface diffusion, a key player in synaptic plasticity, is deregulated in multiple HD mouse models as a result of impaired BDNF signalling that underlies the memory deficits, and can be pharmacologically rescued.Hongyu ZhangChunlei ZhangJean VincentDiana ZalaCaroline BenstaaliMatthieu SainlosDolors Grillo-BoschSophie DaburonFrançoise CoussenYoon ChoDenis J. DavidFrederic SaudouYann HumeauDaniel ChoquetNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hongyu Zhang Chunlei Zhang Jean Vincent Diana Zala Caroline Benstaali Matthieu Sainlos Dolors Grillo-Bosch Sophie Daburon Françoise Coussen Yoon Cho Denis J. David Frederic Saudou Yann Humeau Daniel Choquet Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington’s disease models
description	Cognitive decline in Huntington’s disease (HD) may be due to impaired hippocampal synaptic plasticity. In this study the authors show that AMPA receptor surface diffusion, a key player in synaptic plasticity, is deregulated in multiple HD mouse models as a result of impaired BDNF signalling that underlies the memory deficits, and can be pharmacologically rescued.
format	article
author	Hongyu Zhang Chunlei Zhang Jean Vincent Diana Zala Caroline Benstaali Matthieu Sainlos Dolors Grillo-Bosch Sophie Daburon Françoise Coussen Yoon Cho Denis J. David Frederic Saudou Yann Humeau Daniel Choquet
author_facet	Hongyu Zhang Chunlei Zhang Jean Vincent Diana Zala Caroline Benstaali Matthieu Sainlos Dolors Grillo-Bosch Sophie Daburon Françoise Coussen Yoon Cho Denis J. David Frederic Saudou Yann Humeau Daniel Choquet
author_sort	Hongyu Zhang
title	Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington’s disease models
title_short	Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington’s disease models
title_full	Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington’s disease models
title_fullStr	Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington’s disease models
title_full_unstemmed	Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington’s disease models
title_sort	modulation of ampa receptor surface diffusion restores hippocampal plasticity and memory in huntington’s disease models
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ddde984bb066475ab87f81ec554c5d91
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Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington’s disease models

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