NAD+ augmentation with nicotinamide riboside improves lymphoid potential of Atm −/− and old mice HSCs

Abstract NAD+ supplementation has significant benefits in compromised settings, acting largely through improved mitochondrial function and DNA repair. Elevating NAD+ to physiological levels has been shown to improve the function of some adult stem cells, with implications that these changes will lea...

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Autores principales:	Le Zong, Mayuri Tanaka-Yano, Bongsoo Park, Hagai Yanai, Ferda T. Turhan, Deborah L. Croteau, Jane Tian, Evandro F. Fang, Vilhelm A. Bohr, Isabel Beerman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/ddf050c242524dbc83af057e4f93df30
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spelling	oai:doaj.org-article:ddf050c242524dbc83af057e4f93df302021-12-02T18:14:07ZNAD+ augmentation with nicotinamide riboside improves lymphoid potential of Atm −/− and old mice HSCs10.1038/s41514-021-00078-32056-3973https://doaj.org/article/ddf050c242524dbc83af057e4f93df302021-09-01T00:00:00Zhttps://doi.org/10.1038/s41514-021-00078-3https://doaj.org/toc/2056-3973Abstract NAD+ supplementation has significant benefits in compromised settings, acting largely through improved mitochondrial function and DNA repair. Elevating NAD+ to physiological levels has been shown to improve the function of some adult stem cells, with implications that these changes will lead to sustained improvement of the tissue or system. Here, we examined the effect of elevating NAD+ levels in models with reduced hematopoietic stem cell (HSC) potential, ATM-deficient and aged WT mice, and showed that supplementation of nicotinamide riboside (NR), a NAD+ precursor, improved lymphoid lineage potential during supplementation. In aged mice, this improved lymphoid potential was maintained in competitive transplants and was associated with transcriptional repression of myeloid gene signatures in stem and lineage-committed progenitor cells after NR treatment. However, the altered transcriptional priming of the stem cells toward lymphoid lineages was not sustained in the aged mice after NR removal. These data characterize significant alterations to the lineage potential of functionally compromised HSCs after short-term exposure to NR treatment.Le ZongMayuri Tanaka-YanoBongsoo ParkHagai YanaiFerda T. TurhanDeborah L. CroteauJane TianEvandro F. FangVilhelm A. BohrIsabel BeermanNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 7, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Le Zong Mayuri Tanaka-Yano Bongsoo Park Hagai Yanai Ferda T. Turhan Deborah L. Croteau Jane Tian Evandro F. Fang Vilhelm A. Bohr Isabel Beerman NAD+ augmentation with nicotinamide riboside improves lymphoid potential of Atm −/− and old mice HSCs
description	Abstract NAD+ supplementation has significant benefits in compromised settings, acting largely through improved mitochondrial function and DNA repair. Elevating NAD+ to physiological levels has been shown to improve the function of some adult stem cells, with implications that these changes will lead to sustained improvement of the tissue or system. Here, we examined the effect of elevating NAD+ levels in models with reduced hematopoietic stem cell (HSC) potential, ATM-deficient and aged WT mice, and showed that supplementation of nicotinamide riboside (NR), a NAD+ precursor, improved lymphoid lineage potential during supplementation. In aged mice, this improved lymphoid potential was maintained in competitive transplants and was associated with transcriptional repression of myeloid gene signatures in stem and lineage-committed progenitor cells after NR treatment. However, the altered transcriptional priming of the stem cells toward lymphoid lineages was not sustained in the aged mice after NR removal. These data characterize significant alterations to the lineage potential of functionally compromised HSCs after short-term exposure to NR treatment.
format	article
author	Le Zong Mayuri Tanaka-Yano Bongsoo Park Hagai Yanai Ferda T. Turhan Deborah L. Croteau Jane Tian Evandro F. Fang Vilhelm A. Bohr Isabel Beerman
author_facet	Le Zong Mayuri Tanaka-Yano Bongsoo Park Hagai Yanai Ferda T. Turhan Deborah L. Croteau Jane Tian Evandro F. Fang Vilhelm A. Bohr Isabel Beerman
author_sort	Le Zong
title	NAD+ augmentation with nicotinamide riboside improves lymphoid potential of Atm −/− and old mice HSCs
title_short	NAD+ augmentation with nicotinamide riboside improves lymphoid potential of Atm −/− and old mice HSCs
title_full	NAD+ augmentation with nicotinamide riboside improves lymphoid potential of Atm −/− and old mice HSCs
title_fullStr	NAD+ augmentation with nicotinamide riboside improves lymphoid potential of Atm −/− and old mice HSCs
title_full_unstemmed	NAD+ augmentation with nicotinamide riboside improves lymphoid potential of Atm −/− and old mice HSCs
title_sort	nad+ augmentation with nicotinamide riboside improves lymphoid potential of atm −/− and old mice hscs
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ddf050c242524dbc83af057e4f93df30
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NAD+ augmentation with nicotinamide riboside improves lymphoid potential of Atm −/− and old mice HSCs

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