Suppression of HSF1 activity by wildtype p53 creates a driving force for p53 loss-of-heterozygosity
Most mutant p53 heterozygous tumours undergo loss of the remaining wildtype (WT) p53 allele which leads to stabilization of the mutant p53 protein. Here, the authors show in an autochthonous colorectal cancer model that the WT p53 allele retains partial activity and suppresses the heat shock factor...
Enregistré dans:
| Auteurs principaux: | , , , , , , , , , |
|---|---|
| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2021
|
| Sujets: | |
| Accès en ligne: | https://doaj.org/article/ddfeb1901f9c402d9ea06899ab0fe557 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|