Suppression of HSF1 activity by wildtype p53 creates a driving force for p53 loss-of-heterozygosity

Most mutant p53 heterozygous tumours undergo loss of the remaining wildtype (WT) p53 allele which leads to stabilization of the mutant p53 protein. Here, the authors show in an autochthonous colorectal cancer model that the WT p53 allele retains partial activity and suppresses the heat shock factor...

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Autores principales:	Tamara Isermann, Özge Çiçek Şener, Adrian Stender, Luisa Klemke, Nadine Winkler, Albrecht Neesse, Jinyu Li, Florian Wegwitz, Ute M. Moll, Ramona Schulz-Heddergott
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ddfeb1901f9c402d9ea06899ab0fe557
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spelling	oai:doaj.org-article:ddfeb1901f9c402d9ea06899ab0fe5572021-12-02T14:34:06ZSuppression of HSF1 activity by wildtype p53 creates a driving force for p53 loss-of-heterozygosity10.1038/s41467-021-24064-12041-1723https://doaj.org/article/ddfeb1901f9c402d9ea06899ab0fe5572021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24064-1https://doaj.org/toc/2041-1723Most mutant p53 heterozygous tumours undergo loss of the remaining wildtype (WT) p53 allele which leads to stabilization of the mutant p53 protein. Here, the authors show in an autochthonous colorectal cancer model that the WT p53 allele retains partial activity and suppresses the heat shock factor 1 (HSF1)- chaperone axis to prevent mutant p53 stabilisation and mutant p53 gain-of-function activities, thereby creating selective pressure for p53 loss-of-heterozygosity.Tamara IsermannÖzge Çiçek ŞenerAdrian StenderLuisa KlemkeNadine WinklerAlbrecht NeesseJinyu LiFlorian WegwitzUte M. MollRamona Schulz-HeddergottNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tamara Isermann Özge Çiçek Şener Adrian Stender Luisa Klemke Nadine Winkler Albrecht Neesse Jinyu Li Florian Wegwitz Ute M. Moll Ramona Schulz-Heddergott Suppression of HSF1 activity by wildtype p53 creates a driving force for p53 loss-of-heterozygosity
description	Most mutant p53 heterozygous tumours undergo loss of the remaining wildtype (WT) p53 allele which leads to stabilization of the mutant p53 protein. Here, the authors show in an autochthonous colorectal cancer model that the WT p53 allele retains partial activity and suppresses the heat shock factor 1 (HSF1)- chaperone axis to prevent mutant p53 stabilisation and mutant p53 gain-of-function activities, thereby creating selective pressure for p53 loss-of-heterozygosity.
format	article
author	Tamara Isermann Özge Çiçek Şener Adrian Stender Luisa Klemke Nadine Winkler Albrecht Neesse Jinyu Li Florian Wegwitz Ute M. Moll Ramona Schulz-Heddergott
author_facet	Tamara Isermann Özge Çiçek Şener Adrian Stender Luisa Klemke Nadine Winkler Albrecht Neesse Jinyu Li Florian Wegwitz Ute M. Moll Ramona Schulz-Heddergott
author_sort	Tamara Isermann
title	Suppression of HSF1 activity by wildtype p53 creates a driving force for p53 loss-of-heterozygosity
title_short	Suppression of HSF1 activity by wildtype p53 creates a driving force for p53 loss-of-heterozygosity
title_full	Suppression of HSF1 activity by wildtype p53 creates a driving force for p53 loss-of-heterozygosity
title_fullStr	Suppression of HSF1 activity by wildtype p53 creates a driving force for p53 loss-of-heterozygosity
title_full_unstemmed	Suppression of HSF1 activity by wildtype p53 creates a driving force for p53 loss-of-heterozygosity
title_sort	suppression of hsf1 activity by wildtype p53 creates a driving force for p53 loss-of-heterozygosity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ddfeb1901f9c402d9ea06899ab0fe557
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Suppression of HSF1 activity by wildtype p53 creates a driving force for p53 loss-of-heterozygosity

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