Male germ cells support long-term propagation of Zika virus

Zika virus (ZIKV) can persist for months in semen and sperm. Here, the authors show that germ cells, compared to other cell types in the reproductive tract, are most susceptible to ZIKV and produce high levels of progeny virus, which coincides with decreased expression of the interferon-stimulated g...

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Autores principales:	Christopher L. Robinson, Angie C. N. Chong, Alison W. Ashbrook, Ginnie Jeng, Julia Jin, Haiqi Chen, Elizabeth I. Tang, Laura A. Martin, Rosa S. Kim, Reyn M. Kenyon, Eileen Do, Joseph M. Luna, Mohsan Saeed, Lori Zeltser, Harold Ralph, Vanessa L. Dudley, Marc Goldstein, Charles M. Rice, C. Yan Cheng, Marco Seandel, Shuibing Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/de04bd349fab404aa0fe17716eae5931
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spelling	oai:doaj.org-article:de04bd349fab404aa0fe17716eae59312021-12-02T17:32:16ZMale germ cells support long-term propagation of Zika virus10.1038/s41467-018-04444-w2041-1723https://doaj.org/article/de04bd349fab404aa0fe17716eae59312018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04444-whttps://doaj.org/toc/2041-1723Zika virus (ZIKV) can persist for months in semen and sperm. Here, the authors show that germ cells, compared to other cell types in the reproductive tract, are most susceptible to ZIKV and produce high levels of progeny virus, which coincides with decreased expression of the interferon-stimulated gene Ifi44l.Christopher L. RobinsonAngie C. N. ChongAlison W. AshbrookGinnie JengJulia JinHaiqi ChenElizabeth I. TangLaura A. MartinRosa S. KimReyn M. KenyonEileen DoJoseph M. LunaMohsan SaeedLori ZeltserHarold RalphVanessa L. DudleyMarc GoldsteinCharles M. RiceC. Yan ChengMarco SeandelShuibing ChenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christopher L. Robinson Angie C. N. Chong Alison W. Ashbrook Ginnie Jeng Julia Jin Haiqi Chen Elizabeth I. Tang Laura A. Martin Rosa S. Kim Reyn M. Kenyon Eileen Do Joseph M. Luna Mohsan Saeed Lori Zeltser Harold Ralph Vanessa L. Dudley Marc Goldstein Charles M. Rice C. Yan Cheng Marco Seandel Shuibing Chen Male germ cells support long-term propagation of Zika virus
description	Zika virus (ZIKV) can persist for months in semen and sperm. Here, the authors show that germ cells, compared to other cell types in the reproductive tract, are most susceptible to ZIKV and produce high levels of progeny virus, which coincides with decreased expression of the interferon-stimulated gene Ifi44l.
format	article
author	Christopher L. Robinson Angie C. N. Chong Alison W. Ashbrook Ginnie Jeng Julia Jin Haiqi Chen Elizabeth I. Tang Laura A. Martin Rosa S. Kim Reyn M. Kenyon Eileen Do Joseph M. Luna Mohsan Saeed Lori Zeltser Harold Ralph Vanessa L. Dudley Marc Goldstein Charles M. Rice C. Yan Cheng Marco Seandel Shuibing Chen
author_facet	Christopher L. Robinson Angie C. N. Chong Alison W. Ashbrook Ginnie Jeng Julia Jin Haiqi Chen Elizabeth I. Tang Laura A. Martin Rosa S. Kim Reyn M. Kenyon Eileen Do Joseph M. Luna Mohsan Saeed Lori Zeltser Harold Ralph Vanessa L. Dudley Marc Goldstein Charles M. Rice C. Yan Cheng Marco Seandel Shuibing Chen
author_sort	Christopher L. Robinson
title	Male germ cells support long-term propagation of Zika virus
title_short	Male germ cells support long-term propagation of Zika virus
title_full	Male germ cells support long-term propagation of Zika virus
title_fullStr	Male germ cells support long-term propagation of Zika virus
title_full_unstemmed	Male germ cells support long-term propagation of Zika virus
title_sort	male germ cells support long-term propagation of zika virus
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/de04bd349fab404aa0fe17716eae5931
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Male germ cells support long-term propagation of Zika virus

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