Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence

Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence

Replication defective viral genomes (DVGs) can facilitate persistence of paramyxoviruses, but the underlying mechanisms are unclear. Using FISH, Xu et al. here analyze the cellular response to DVGs on a single cell level and show that a MAVS-mediated TNF response specifically extends survival of cel...

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Main Authors: Jie Xu, Yan Sun, Yize Li, Gordon Ruthel, Susan R. Weiss, Arjun Raj, Daniel Beiting, Carolina B. López
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Science
Q
Online Access:https://doaj.org/article/de04deb85ee9444f8080c1d3da9a63d7
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spelling oai:doaj.org-article:de04deb85ee9444f8080c1d3da9a63d72021-12-02T17:06:15ZReplication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence10.1038/s41467-017-00909-62041-1723https://doaj.org/article/de04deb85ee9444f8080c1d3da9a63d72017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00909-6https://doaj.org/toc/2041-1723Replication defective viral genomes (DVGs) can facilitate persistence of paramyxoviruses, but the underlying mechanisms are unclear. Using FISH, Xu et al. here analyze the cellular response to DVGs on a single cell level and show that a MAVS-mediated TNF response specifically extends survival of cells enriched in DVGs.Jie XuYan SunYize LiGordon RuthelSusan R. WeissArjun RajDaniel BeitingCarolina B. LópezNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jie Xu
Yan Sun
Yize Li
Gordon Ruthel
Susan R. Weiss
Arjun Raj
Daniel Beiting
Carolina B. López
Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence
description Replication defective viral genomes (DVGs) can facilitate persistence of paramyxoviruses, but the underlying mechanisms are unclear. Using FISH, Xu et al. here analyze the cellular response to DVGs on a single cell level and show that a MAVS-mediated TNF response specifically extends survival of cells enriched in DVGs.
format article
author Jie Xu
Yan Sun
Yize Li
Gordon Ruthel
Susan R. Weiss
Arjun Raj
Daniel Beiting
Carolina B. López
author_facet Jie Xu
Yan Sun
Yize Li
Gordon Ruthel
Susan R. Weiss
Arjun Raj
Daniel Beiting
Carolina B. López
author_sort Jie Xu
title Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence
title_short Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence
title_full Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence
title_fullStr Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence
title_full_unstemmed Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence
title_sort replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/de04deb85ee9444f8080c1d3da9a63d7
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AT gordonruthel replicationdefectiveviralgenomesexploitacellularprosurvivalmechanismtoestablishparamyxoviruspersistence
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AT danielbeiting replicationdefectiveviralgenomesexploitacellularprosurvivalmechanismtoestablishparamyxoviruspersistence
AT carolinablopez replicationdefectiveviralgenomesexploitacellularprosurvivalmechanismtoestablishparamyxoviruspersistence
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