The cooperative binding of TDP-43 to GU-rich RNA repeats antagonizes TDP-43 aggregation

TDP-43 is a nuclear RNA-binding protein that forms neuronal cytoplasmic inclusions in two major neurodegenerative diseases, ALS and FTLD. While the self-assembly of TDP-43 by its structured N-terminal and intrinsically disordered C-terminal domains has been widely studied, the mechanism by which mRN...

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Autores principales: Juan Carlos Rengifo-Gonzalez, Krystel El Hage, Marie-Jeanne Clément, Emilie Steiner, Vandana Joshi, Pierrick Craveur, Dominique Durand, David Pastré, Ahmed Bouhss
Formato: article
Lenguaje:EN
Publicado: eLife Sciences Publications Ltd 2021
Materias:
RNA
R
Q
Acceso en línea:https://doaj.org/article/de0ec8831ecd4f1da1a28a35d038e526
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