MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation

The circadian clock and the cell cycle systems coordinate global physiology. Here the authors show that MYC represses the clock genes, together with MIZ1, and induces proliferation, suggesting that MYC inversely modulates cell cycle and circadian clock genes.

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Autores principales:	Anton Shostak, Bianca Ruppert, Nati Ha, Philipp Bruns, Umut H. Toprak, ICGC MMML-Seq Project, Roland Eils, Matthias Schlesner, Axel Diernfellner, Michael Brunner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/de2a1204a90241d887fa042addd3ea10
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spelling	oai:doaj.org-article:de2a1204a90241d887fa042addd3ea102021-12-02T16:58:23ZMYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation10.1038/ncomms118072041-1723https://doaj.org/article/de2a1204a90241d887fa042addd3ea102016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11807https://doaj.org/toc/2041-1723The circadian clock and the cell cycle systems coordinate global physiology. Here the authors show that MYC represses the clock genes, together with MIZ1, and induces proliferation, suggesting that MYC inversely modulates cell cycle and circadian clock genes.Anton ShostakBianca RuppertNati HaPhilipp BrunsUmut H. ToprakICGC MMML-Seq ProjectRoland EilsMatthias SchlesnerAxel DiernfellnerMichael BrunnerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anton Shostak Bianca Ruppert Nati Ha Philipp Bruns Umut H. Toprak ICGC MMML-Seq Project Roland Eils Matthias Schlesner Axel Diernfellner Michael Brunner MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation
description	The circadian clock and the cell cycle systems coordinate global physiology. Here the authors show that MYC represses the clock genes, together with MIZ1, and induces proliferation, suggesting that MYC inversely modulates cell cycle and circadian clock genes.
format	article
author	Anton Shostak Bianca Ruppert Nati Ha Philipp Bruns Umut H. Toprak ICGC MMML-Seq Project Roland Eils Matthias Schlesner Axel Diernfellner Michael Brunner
author_facet	Anton Shostak Bianca Ruppert Nati Ha Philipp Bruns Umut H. Toprak ICGC MMML-Seq Project Roland Eils Matthias Schlesner Axel Diernfellner Michael Brunner
author_sort	Anton Shostak
title	MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation
title_short	MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation
title_full	MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation
title_fullStr	MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation
title_full_unstemmed	MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation
title_sort	myc/miz1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/de2a1204a90241d887fa042addd3ea10
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MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation

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