Enhanced immunocompatibility of ligand-targeted liposomes by attenuating natural IgM absorption

Targeting ligands on drug carriers can trigger immune responses. Here, the authors modify liposomes with a peptidomimetic that preserves bioactivity of the nanocarrier in blood circulation and attenuates IgM absorption, thereby improving the immunocompatibility of brain-targeted liposomes.

Guardado en:

Detalles Bibliográficos
Autores principales:	Juan Guan, Qing Shen, Zui Zhang, Zhuxuan Jiang, Yang Yang, Meiqing Lou, Jun Qian, Weiyue Lu, Changyou Zhan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/de6780060c3d401faf616e76a93f9070
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:de6780060c3d401faf616e76a93f9070
record_format	dspace
spelling	oai:doaj.org-article:de6780060c3d401faf616e76a93f90702021-12-02T17:32:31ZEnhanced immunocompatibility of ligand-targeted liposomes by attenuating natural IgM absorption10.1038/s41467-018-05384-12041-1723https://doaj.org/article/de6780060c3d401faf616e76a93f90702018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05384-1https://doaj.org/toc/2041-1723Targeting ligands on drug carriers can trigger immune responses. Here, the authors modify liposomes with a peptidomimetic that preserves bioactivity of the nanocarrier in blood circulation and attenuates IgM absorption, thereby improving the immunocompatibility of brain-targeted liposomes.Juan GuanQing ShenZui ZhangZhuxuan JiangYang YangMeiqing LouJun QianWeiyue LuChangyou ZhanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Juan Guan Qing Shen Zui Zhang Zhuxuan Jiang Yang Yang Meiqing Lou Jun Qian Weiyue Lu Changyou Zhan Enhanced immunocompatibility of ligand-targeted liposomes by attenuating natural IgM absorption
description	Targeting ligands on drug carriers can trigger immune responses. Here, the authors modify liposomes with a peptidomimetic that preserves bioactivity of the nanocarrier in blood circulation and attenuates IgM absorption, thereby improving the immunocompatibility of brain-targeted liposomes.
format	article
author	Juan Guan Qing Shen Zui Zhang Zhuxuan Jiang Yang Yang Meiqing Lou Jun Qian Weiyue Lu Changyou Zhan
author_facet	Juan Guan Qing Shen Zui Zhang Zhuxuan Jiang Yang Yang Meiqing Lou Jun Qian Weiyue Lu Changyou Zhan
author_sort	Juan Guan
title	Enhanced immunocompatibility of ligand-targeted liposomes by attenuating natural IgM absorption
title_short	Enhanced immunocompatibility of ligand-targeted liposomes by attenuating natural IgM absorption
title_full	Enhanced immunocompatibility of ligand-targeted liposomes by attenuating natural IgM absorption
title_fullStr	Enhanced immunocompatibility of ligand-targeted liposomes by attenuating natural IgM absorption
title_full_unstemmed	Enhanced immunocompatibility of ligand-targeted liposomes by attenuating natural IgM absorption
title_sort	enhanced immunocompatibility of ligand-targeted liposomes by attenuating natural igm absorption
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/de6780060c3d401faf616e76a93f9070
work_keys_str_mv	AT juanguan enhancedimmunocompatibilityofligandtargetedliposomesbyattenuatingnaturaligmabsorption AT qingshen enhancedimmunocompatibilityofligandtargetedliposomesbyattenuatingnaturaligmabsorption AT zuizhang enhancedimmunocompatibilityofligandtargetedliposomesbyattenuatingnaturaligmabsorption AT zhuxuanjiang enhancedimmunocompatibilityofligandtargetedliposomesbyattenuatingnaturaligmabsorption AT yangyang enhancedimmunocompatibilityofligandtargetedliposomesbyattenuatingnaturaligmabsorption AT meiqinglou enhancedimmunocompatibilityofligandtargetedliposomesbyattenuatingnaturaligmabsorption AT junqian enhancedimmunocompatibilityofligandtargetedliposomesbyattenuatingnaturaligmabsorption AT weiyuelu enhancedimmunocompatibilityofligandtargetedliposomesbyattenuatingnaturaligmabsorption AT changyouzhan enhancedimmunocompatibilityofligandtargetedliposomesbyattenuatingnaturaligmabsorption
_version_	1718380279653990400

Enhanced immunocompatibility of ligand-targeted liposomes by attenuating natural IgM absorption

Ejemplares similares