Real-space and real-time dynamics of CRISPR-Cas9 visualized by high-speed atomic force microscopy

Real-space and real-time dynamics of CRISPR-Cas9 visualized by high-speed atomic force microscopy

CRISPR RNA-guided endonuclease Cas9 recognizes and cleaves the double-stranded DNA complementary to the RNA guide. Here the authors use high-speed atomic force micropcopy (HS-AFM) to visualize the conformational dynamics of Cas9 during its DNA targeting and cleavage processes.

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Autores principales: Mikihiro Shibata, Hiroshi Nishimasu, Noriyuki Kodera, Seiichi Hirano, Toshio Ando, Takayuki Uchihashi, Osamu Nureki
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/de85d8052fbc4273b32ea84729525771
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