The WNT1 G177C mutation specifically affects skeletal integrity in a mouse model of osteogenesis imperfecta type XV

Abstract The recent identification of homozygous WNT1 mutations in individuals with osteogenesis imperfecta type XV (OI-XV) has suggested that WNT1 is a key ligand promoting the differentiation and function of bone-forming osteoblasts. Although such an influence was supported by subsequent studies,...

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Autores principales:	Nele Vollersen, Wenbo Zhao, Tim Rolvien, Fabiola Lange, Felix Nikolai Schmidt, Stephan Sonntag, Doron Shmerling, Simon von Kroge, Kilian Elia Stockhausen, Ahmed Sharaf, Michaela Schweizer, Meliha Karsak, Björn Busse, Ernesto Bockamp, Oliver Semler, Michael Amling, Ralf Oheim, Thorsten Schinke, Timur Alexander Yorgan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Biology (General) QH301-705.5 Physiology QP1-981
Acceso en línea:	https://doaj.org/article/dec15195222f43c6a21a6c77c8ffa7fd
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The WNT1 G177C mutation specifically affects skeletal integrity in a mouse model of osteogenesis imperfecta type XV

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