Small molecule regulated sgRNAs enable control of genome editing in E. coli by Cas9

Bacteria lack the same suite of CRISPR tools that have been developed for mammalian cells. Here, the authors link aptamers to sgRNAs to allow small molecule control of gene editing in E. coli.

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Autores principales:	Roman S. Iwasaki, Bagdeser A. Ozdilek, Andrew D. Garst, Alaksh Choudhury, Robert T. Batey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ded3f93171cd4f4bb57d5a441ed60ade
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spelling	oai:doaj.org-article:ded3f93171cd4f4bb57d5a441ed60ade2021-12-02T13:31:14ZSmall molecule regulated sgRNAs enable control of genome editing in E. coli by Cas910.1038/s41467-020-15226-82041-1723https://doaj.org/article/ded3f93171cd4f4bb57d5a441ed60ade2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15226-8https://doaj.org/toc/2041-1723Bacteria lack the same suite of CRISPR tools that have been developed for mammalian cells. Here, the authors link aptamers to sgRNAs to allow small molecule control of gene editing in E. coli.Roman S. IwasakiBagdeser A. OzdilekAndrew D. GarstAlaksh ChoudhuryRobert T. BateyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Roman S. Iwasaki Bagdeser A. Ozdilek Andrew D. Garst Alaksh Choudhury Robert T. Batey Small molecule regulated sgRNAs enable control of genome editing in E. coli by Cas9
description	Bacteria lack the same suite of CRISPR tools that have been developed for mammalian cells. Here, the authors link aptamers to sgRNAs to allow small molecule control of gene editing in E. coli.
format	article
author	Roman S. Iwasaki Bagdeser A. Ozdilek Andrew D. Garst Alaksh Choudhury Robert T. Batey
author_facet	Roman S. Iwasaki Bagdeser A. Ozdilek Andrew D. Garst Alaksh Choudhury Robert T. Batey
author_sort	Roman S. Iwasaki
title	Small molecule regulated sgRNAs enable control of genome editing in E. coli by Cas9
title_short	Small molecule regulated sgRNAs enable control of genome editing in E. coli by Cas9
title_full	Small molecule regulated sgRNAs enable control of genome editing in E. coli by Cas9
title_fullStr	Small molecule regulated sgRNAs enable control of genome editing in E. coli by Cas9
title_full_unstemmed	Small molecule regulated sgRNAs enable control of genome editing in E. coli by Cas9
title_sort	small molecule regulated sgrnas enable control of genome editing in e. coli by cas9
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ded3f93171cd4f4bb57d5a441ed60ade
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Small molecule regulated sgRNAs enable control of genome editing in E. coli by Cas9

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