Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric diketopiperazines

Bacterial heterodimeric tryptophan-containing diketopiperazines (HTDKPs) are bioactive natural products that are difficult to access chemically. Here, the authors identify a family of three related HTDKP-forming cytochrome P450s and engineer key amino acid residues to produce distinct diketopiperazi...

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Autores principales:	Chenghai Sun, Zhenyao Luo, Wenlu Zhang, Wenya Tian, Haidong Peng, Zhi Lin, Zixin Deng, Bostjan Kobe, Xinying Jia, Xudong Qu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/deec282f340c466fb789659b31294f4e
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spelling	oai:doaj.org-article:deec282f340c466fb789659b31294f4e2021-12-02T10:48:19ZMolecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric diketopiperazines10.1038/s41467-020-20022-52041-1723https://doaj.org/article/deec282f340c466fb789659b31294f4e2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20022-5https://doaj.org/toc/2041-1723Bacterial heterodimeric tryptophan-containing diketopiperazines (HTDKPs) are bioactive natural products that are difficult to access chemically. Here, the authors identify a family of three related HTDKP-forming cytochrome P450s and engineer key amino acid residues to produce distinct diketopiperazines frameworks.Chenghai SunZhenyao LuoWenlu ZhangWenya TianHaidong PengZhi LinZixin DengBostjan KobeXinying JiaXudong QuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chenghai Sun Zhenyao Luo Wenlu Zhang Wenya Tian Haidong Peng Zhi Lin Zixin Deng Bostjan Kobe Xinying Jia Xudong Qu Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric diketopiperazines
description	Bacterial heterodimeric tryptophan-containing diketopiperazines (HTDKPs) are bioactive natural products that are difficult to access chemically. Here, the authors identify a family of three related HTDKP-forming cytochrome P450s and engineer key amino acid residues to produce distinct diketopiperazines frameworks.
format	article
author	Chenghai Sun Zhenyao Luo Wenlu Zhang Wenya Tian Haidong Peng Zhi Lin Zixin Deng Bostjan Kobe Xinying Jia Xudong Qu
author_facet	Chenghai Sun Zhenyao Luo Wenlu Zhang Wenya Tian Haidong Peng Zhi Lin Zixin Deng Bostjan Kobe Xinying Jia Xudong Qu
author_sort	Chenghai Sun
title	Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric diketopiperazines
title_short	Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric diketopiperazines
title_full	Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric diketopiperazines
title_fullStr	Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric diketopiperazines
title_full_unstemmed	Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric diketopiperazines
title_sort	molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric diketopiperazines
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/deec282f340c466fb789659b31294f4e
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Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric diketopiperazines

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