Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric diketopiperazines

Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric diketopiperazines

Bacterial heterodimeric tryptophan-containing diketopiperazines (HTDKPs) are bioactive natural products that are difficult to access chemically. Here, the authors identify a family of three related HTDKP-forming cytochrome P450s and engineer key amino acid residues to produce distinct diketopiperazi...

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Autores principales: Chenghai Sun, Zhenyao Luo, Wenlu Zhang, Wenya Tian, Haidong Peng, Zhi Lin, Zixin Deng, Bostjan Kobe, Xinying Jia, Xudong Qu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/deec282f340c466fb789659b31294f4e
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