Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells

ARID1A is highly inactivated in cancer. Here, the authors show that ARID1A has a synthetic lethal interaction with AURKA in colorectal cancer cells and that ARID1A deficiency activates the AURKA target CDC25C, whose inhibitors also cause cell death in the ARID1A-deficient cell lines.

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Detalles Bibliográficos
Autores principales: Changjie Wu, Junfang Lyu, Eun Ju Yang, Yifan Liu, Baoyuan Zhang, Joong Sup Shim
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/df2b605cb3254b96835e03cc52650794
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