Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells

ARID1A is highly inactivated in cancer. Here, the authors show that ARID1A has a synthetic lethal interaction with AURKA in colorectal cancer cells and that ARID1A deficiency activates the AURKA target CDC25C, whose inhibitors also cause cell death in the ARID1A-deficient cell lines.

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Autores principales:	Changjie Wu, Junfang Lyu, Eun Ju Yang, Yifan Liu, Baoyuan Zhang, Joong Sup Shim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/df2b605cb3254b96835e03cc52650794
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spelling	oai:doaj.org-article:df2b605cb3254b96835e03cc526507942021-12-02T14:39:48ZTargeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells10.1038/s41467-018-05694-42041-1723https://doaj.org/article/df2b605cb3254b96835e03cc526507942018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05694-4https://doaj.org/toc/2041-1723ARID1A is highly inactivated in cancer. Here, the authors show that ARID1A has a synthetic lethal interaction with AURKA in colorectal cancer cells and that ARID1A deficiency activates the AURKA target CDC25C, whose inhibitors also cause cell death in the ARID1A-deficient cell lines.Changjie WuJunfang LyuEun Ju YangYifan LiuBaoyuan ZhangJoong Sup ShimNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Changjie Wu Junfang Lyu Eun Ju Yang Yifan Liu Baoyuan Zhang Joong Sup Shim Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells
description	ARID1A is highly inactivated in cancer. Here, the authors show that ARID1A has a synthetic lethal interaction with AURKA in colorectal cancer cells and that ARID1A deficiency activates the AURKA target CDC25C, whose inhibitors also cause cell death in the ARID1A-deficient cell lines.
format	article
author	Changjie Wu Junfang Lyu Eun Ju Yang Yifan Liu Baoyuan Zhang Joong Sup Shim
author_facet	Changjie Wu Junfang Lyu Eun Ju Yang Yifan Liu Baoyuan Zhang Joong Sup Shim
author_sort	Changjie Wu
title	Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells
title_short	Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells
title_full	Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells
title_fullStr	Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells
title_full_unstemmed	Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells
title_sort	targeting aurka-cdc25c axis to induce synthetic lethality in arid1a-deficient colorectal cancer cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/df2b605cb3254b96835e03cc52650794
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Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells

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