Rare CASP6N73T variant associated with hippocampal volume exhibits decreased proteolytic activity, synaptic transmission defect, and neurodegeneration

Rare CASP6N73T variant associated with hippocampal volume exhibits decreased proteolytic activity, synaptic transmission defect, and neurodegeneration

Abstract Caspase-6 (Casp6) is implicated in Alzheimer disease (AD) cognitive impairment and pathology. Hippocampal atrophy is associated with cognitive impairment in AD. Here, a rare functional exonic missense CASP6 single nucleotide polymorphism (SNP), causing the substitution of asparagine with th...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Libin Zhou, Kwangsik Nho, Maria G. Haddad, Nicole Cherepacha, Agne Tubeleviciute-Aydin, Andy P. Tsai, Andrew J. Saykin, P. Jesper Sjöström, Andrea C. LeBlanc
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/df2d07c515494ee380343cce22ca3145
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Internet

https://doaj.org/article/df2d07c515494ee380343cce22ca3145

Ejemplares similares