Intriguing role of water in protein-ligand binding studied by neutron crystallography on trypsin complexes

Trypsin is a serine protease. Here the authors present the high resolution X-ray and neutron diffraction structures of uncomplexed and inhibitor bound trypsin that provide insights into the geometry of H-bonds in the active site of the enzyme and molecular dynamics simulations reveal the kinetics of...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Johannes Schiebel, Roberto Gaspari, Tobias Wulsdorf, Khang Ngo, Christian Sohn, Tobias E. Schrader, Andrea Cavalli, Andreas Ostermann, Andreas Heine, Gerhard Klebe
Format: article
Langue:EN
Publié: Nature Portfolio 2018
Sujets:
Q
Accès en ligne:https://doaj.org/article/dfa101099f7848ffada5601ea4aa65b1
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!