Intriguing role of water in protein-ligand binding studied by neutron crystallography on trypsin complexes
Trypsin is a serine protease. Here the authors present the high resolution X-ray and neutron diffraction structures of uncomplexed and inhibitor bound trypsin that provide insights into the geometry of H-bonds in the active site of the enzyme and molecular dynamics simulations reveal the kinetics of...
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Auteurs principaux: | , , , , , , , , , |
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Format: | article |
Langue: | EN |
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Nature Portfolio
2018
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Accès en ligne: | https://doaj.org/article/dfa101099f7848ffada5601ea4aa65b1 |
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