Joint profiling of DNA and proteins in single cells to dissect genotype-phenotype associations in leukemia

It is currently difficult to map DNA variants and surface phenotypes in the same cells, preventing direct linkage of phenotype and genotype. Here the authors report DAb-seq for simultaneous capture of DNA genotype and cell surface phenotype from single cells at high throughput.

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Autores principales:	Benjamin Demaree, Cyrille L. Delley, Harish N. Vasudevan, Cheryl A. C. Peretz, David Ruff, Catherine C. Smith, Adam R. Abate
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dfb07e6143424db5a2a57dd7798d784c
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spelling	oai:doaj.org-article:dfb07e6143424db5a2a57dd7798d784c2021-12-02T13:34:49ZJoint profiling of DNA and proteins in single cells to dissect genotype-phenotype associations in leukemia10.1038/s41467-021-21810-32041-1723https://doaj.org/article/dfb07e6143424db5a2a57dd7798d784c2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21810-3https://doaj.org/toc/2041-1723It is currently difficult to map DNA variants and surface phenotypes in the same cells, preventing direct linkage of phenotype and genotype. Here the authors report DAb-seq for simultaneous capture of DNA genotype and cell surface phenotype from single cells at high throughput.Benjamin DemareeCyrille L. DelleyHarish N. VasudevanCheryl A. C. PeretzDavid RuffCatherine C. SmithAdam R. AbateNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Benjamin Demaree Cyrille L. Delley Harish N. Vasudevan Cheryl A. C. Peretz David Ruff Catherine C. Smith Adam R. Abate Joint profiling of DNA and proteins in single cells to dissect genotype-phenotype associations in leukemia
description	It is currently difficult to map DNA variants and surface phenotypes in the same cells, preventing direct linkage of phenotype and genotype. Here the authors report DAb-seq for simultaneous capture of DNA genotype and cell surface phenotype from single cells at high throughput.
format	article
author	Benjamin Demaree Cyrille L. Delley Harish N. Vasudevan Cheryl A. C. Peretz David Ruff Catherine C. Smith Adam R. Abate
author_facet	Benjamin Demaree Cyrille L. Delley Harish N. Vasudevan Cheryl A. C. Peretz David Ruff Catherine C. Smith Adam R. Abate
author_sort	Benjamin Demaree
title	Joint profiling of DNA and proteins in single cells to dissect genotype-phenotype associations in leukemia
title_short	Joint profiling of DNA and proteins in single cells to dissect genotype-phenotype associations in leukemia
title_full	Joint profiling of DNA and proteins in single cells to dissect genotype-phenotype associations in leukemia
title_fullStr	Joint profiling of DNA and proteins in single cells to dissect genotype-phenotype associations in leukemia
title_full_unstemmed	Joint profiling of DNA and proteins in single cells to dissect genotype-phenotype associations in leukemia
title_sort	joint profiling of dna and proteins in single cells to dissect genotype-phenotype associations in leukemia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dfb07e6143424db5a2a57dd7798d784c
work_keys_str_mv	AT benjamindemaree jointprofilingofdnaandproteinsinsinglecellstodissectgenotypephenotypeassociationsinleukemia AT cyrilleldelley jointprofilingofdnaandproteinsinsinglecellstodissectgenotypephenotypeassociationsinleukemia AT harishnvasudevan jointprofilingofdnaandproteinsinsinglecellstodissectgenotypephenotypeassociationsinleukemia AT cherylacperetz jointprofilingofdnaandproteinsinsinglecellstodissectgenotypephenotypeassociationsinleukemia AT davidruff jointprofilingofdnaandproteinsinsinglecellstodissectgenotypephenotypeassociationsinleukemia AT catherinecsmith jointprofilingofdnaandproteinsinsinglecellstodissectgenotypephenotypeassociationsinleukemia AT adamrabate jointprofilingofdnaandproteinsinsinglecellstodissectgenotypephenotypeassociationsinleukemia
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Joint profiling of DNA and proteins in single cells to dissect genotype-phenotype associations in leukemia

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