Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries

Topologically associating domains (TADs) detected by Hi-C technologies are megabase-scale areas of highly interacting chromatin. Here Gong, Lazaris et al. develop a computational approach to improve the reproducibility of Hi-C contact matrices and stratify TAD boundaries based on their insulating st...

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Autores principales:	Yixiao Gong, Charalampos Lazaris, Theodore Sakellaropoulos, Aurelie Lozano, Prabhanjan Kambadur, Panagiotis Ntziachristos, Iannis Aifantis, Aristotelis Tsirigos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dfd9fb5d66e34649a38ccc25f7137c60
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spelling	oai:doaj.org-article:dfd9fb5d66e34649a38ccc25f7137c602021-12-02T17:33:16ZStratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries10.1038/s41467-018-03017-12041-1723https://doaj.org/article/dfd9fb5d66e34649a38ccc25f7137c602018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03017-1https://doaj.org/toc/2041-1723Topologically associating domains (TADs) detected by Hi-C technologies are megabase-scale areas of highly interacting chromatin. Here Gong, Lazaris et al. develop a computational approach to improve the reproducibility of Hi-C contact matrices and stratify TAD boundaries based on their insulating strength.Yixiao GongCharalampos LazarisTheodore SakellaropoulosAurelie LozanoPrabhanjan KambadurPanagiotis NtziachristosIannis AifantisAristotelis TsirigosNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yixiao Gong Charalampos Lazaris Theodore Sakellaropoulos Aurelie Lozano Prabhanjan Kambadur Panagiotis Ntziachristos Iannis Aifantis Aristotelis Tsirigos Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries
description	Topologically associating domains (TADs) detected by Hi-C technologies are megabase-scale areas of highly interacting chromatin. Here Gong, Lazaris et al. develop a computational approach to improve the reproducibility of Hi-C contact matrices and stratify TAD boundaries based on their insulating strength.
format	article
author	Yixiao Gong Charalampos Lazaris Theodore Sakellaropoulos Aurelie Lozano Prabhanjan Kambadur Panagiotis Ntziachristos Iannis Aifantis Aristotelis Tsirigos
author_facet	Yixiao Gong Charalampos Lazaris Theodore Sakellaropoulos Aurelie Lozano Prabhanjan Kambadur Panagiotis Ntziachristos Iannis Aifantis Aristotelis Tsirigos
author_sort	Yixiao Gong
title	Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries
title_short	Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries
title_full	Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries
title_fullStr	Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries
title_full_unstemmed	Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries
title_sort	stratification of tad boundaries reveals preferential insulation of super-enhancers by strong boundaries
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/dfd9fb5d66e34649a38ccc25f7137c60
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Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries

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