Convergent Evolution Driven by Rifampin Exacerbates the Global Burden of Drug-Resistant <named-content content-type="genus-species">Staphylococcus aureus</named-content>

Convergent Evolution Driven by Rifampin Exacerbates the Global Burden of Drug-Resistant <named-content content-type="genus-species">Staphylococcus aureus</named-content>

ABSTRACT Mutations in the beta-subunit of bacterial RNA polymerase (RpoB) cause resistance to rifampin (Rifr), a critical antibiotic for treatment of multidrug-resistant Staphylococcus aureus. In vitro studies have shown that RpoB mutations confer decreased susceptibility to other antibiotics, but t...

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Auteurs principaux: Romain Guérillot, Anders Gonçalves da Silva, Ian Monk, Stefano Giulieri, Takehiro Tomita, Eloise Alison, Jessica Porter, Sacha Pidot, Wei Gao, Anton Y. Peleg, Torsten Seemann, Timothy P. Stinear, Benjamin P. Howden
Format: article
Langue:EN
Publié: American Society for Microbiology 2018
Sujets:
Staphylococcus aureus
adaptive mutations
adaptive resistance
antibiotic resistance
drug resistance evolution
genomics
Microbiology
QR1-502
Accès en ligne:https://doaj.org/article/dff0eaead17b49d387ed2d1c4aecb738
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https://doaj.org/article/dff0eaead17b49d387ed2d1c4aecb738

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