Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 4: β‐Lactams: amoxicillin and penicillin V
Abstract The specific concentrations of amoxicillin and penicillin V in non‐target feed for food‐producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial c...
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2021
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oai:doaj.org-article:e00518118efa4cccb61b13d5c4a3d7762021-11-23T08:30:51ZMaximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed.
Part 4: β‐Lactams: amoxicillin and penicillin V1831-473210.2903/j.efsa.2021.6855https://doaj.org/article/e00518118efa4cccb61b13d5c4a3d7762021-10-01T00:00:00Zhttps://doi.org/10.2903/j.efsa.2021.6855https://doaj.org/toc/1831-4732Abstract The specific concentrations of amoxicillin and penicillin V in non‐target feed for food‐producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which have an effect in terms of growth promotion/increased yield were assessed by EFSA in collaboration with EMA. Details of the methodology used for this assessment, associated data gaps and uncertainties, are presented in a separate document. To address antimicrobial resistance, the Feed Antimicrobial Resistance Selection Concentration (FARSC) model developed specifically for the assessment was applied. However, due to the lack of data on the parameters required to calculate the FARSC, it was not possible to conclude the assessment until further experimental data become available. To address growth promotion, data from scientific publications obtained from an extensive literature review were used. Levels in feed that showed to have an effect on growth promotion/increased yield were reported for amoxicillin, whilst for penicillin V no suitable data for the assessment were available. It was recommended to carry out studies to generate the data that are required to fill the gaps which prevented the calculation of the FARSC for these two antimicrobials.EFSA Panel on Biological Hazards (BIOHAZ)Konstantinos KoutsoumanisAna AllendeAvelino Alvarez‐OrdóñezDeclan BoltonSara Bover‐CidMarianne ChemalyRobert DaviesAlessandra De CesareLieve HermanFriederike HilbertRoland LindqvistMaarten NautaGiuseppe RuMarion SimmonsPanagiotis SkandamisElisabetta SuffrediniDan I AnderssonVasileios BampidisJohan Bengtsson‐PalmeDamien BouchardAude FerranMaryline KoubaSecundino López PuenteMarta López‐AlonsoSøren Saxmose NielsenAlena PechováMariana PetkovaSebastien GiraultAlessandro BrogliaBeatriz GuerraMatteo Lorenzo InnocentiErnesto LiébanaGloria López‐GálvezPaola ManiniPietro StellaLuisa PeixeWileyarticleamoxicillinpenicillin Vantimicrobial resistancesub‐inhibitory concentrationgrowth promotionyield increaseNutrition. Foods and food supplyTX341-641Chemical technologyTP1-1185ENEFSA Journal, Vol 19, Iss 10, Pp n/a-n/a (2021) |
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amoxicillin penicillin V antimicrobial resistance sub‐inhibitory concentration growth promotion yield increase Nutrition. Foods and food supply TX341-641 Chemical technology TP1-1185 |
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amoxicillin penicillin V antimicrobial resistance sub‐inhibitory concentration growth promotion yield increase Nutrition. Foods and food supply TX341-641 Chemical technology TP1-1185 EFSA Panel on Biological Hazards (BIOHAZ) Konstantinos Koutsoumanis Ana Allende Avelino Alvarez‐Ordóñez Declan Bolton Sara Bover‐Cid Marianne Chemaly Robert Davies Alessandra De Cesare Lieve Herman Friederike Hilbert Roland Lindqvist Maarten Nauta Giuseppe Ru Marion Simmons Panagiotis Skandamis Elisabetta Suffredini Dan I Andersson Vasileios Bampidis Johan Bengtsson‐Palme Damien Bouchard Aude Ferran Maryline Kouba Secundino López Puente Marta López‐Alonso Søren Saxmose Nielsen Alena Pechová Mariana Petkova Sebastien Girault Alessandro Broglia Beatriz Guerra Matteo Lorenzo Innocenti Ernesto Liébana Gloria López‐Gálvez Paola Manini Pietro Stella Luisa Peixe Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 4: β‐Lactams: amoxicillin and penicillin V |
| description |
Abstract The specific concentrations of amoxicillin and penicillin V in non‐target feed for food‐producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which have an effect in terms of growth promotion/increased yield were assessed by EFSA in collaboration with EMA. Details of the methodology used for this assessment, associated data gaps and uncertainties, are presented in a separate document. To address antimicrobial resistance, the Feed Antimicrobial Resistance Selection Concentration (FARSC) model developed specifically for the assessment was applied. However, due to the lack of data on the parameters required to calculate the FARSC, it was not possible to conclude the assessment until further experimental data become available. To address growth promotion, data from scientific publications obtained from an extensive literature review were used. Levels in feed that showed to have an effect on growth promotion/increased yield were reported for amoxicillin, whilst for penicillin V no suitable data for the assessment were available. It was recommended to carry out studies to generate the data that are required to fill the gaps which prevented the calculation of the FARSC for these two antimicrobials. |
| format |
article |
| author |
EFSA Panel on Biological Hazards (BIOHAZ) Konstantinos Koutsoumanis Ana Allende Avelino Alvarez‐Ordóñez Declan Bolton Sara Bover‐Cid Marianne Chemaly Robert Davies Alessandra De Cesare Lieve Herman Friederike Hilbert Roland Lindqvist Maarten Nauta Giuseppe Ru Marion Simmons Panagiotis Skandamis Elisabetta Suffredini Dan I Andersson Vasileios Bampidis Johan Bengtsson‐Palme Damien Bouchard Aude Ferran Maryline Kouba Secundino López Puente Marta López‐Alonso Søren Saxmose Nielsen Alena Pechová Mariana Petkova Sebastien Girault Alessandro Broglia Beatriz Guerra Matteo Lorenzo Innocenti Ernesto Liébana Gloria López‐Gálvez Paola Manini Pietro Stella Luisa Peixe |
| author_facet |
EFSA Panel on Biological Hazards (BIOHAZ) Konstantinos Koutsoumanis Ana Allende Avelino Alvarez‐Ordóñez Declan Bolton Sara Bover‐Cid Marianne Chemaly Robert Davies Alessandra De Cesare Lieve Herman Friederike Hilbert Roland Lindqvist Maarten Nauta Giuseppe Ru Marion Simmons Panagiotis Skandamis Elisabetta Suffredini Dan I Andersson Vasileios Bampidis Johan Bengtsson‐Palme Damien Bouchard Aude Ferran Maryline Kouba Secundino López Puente Marta López‐Alonso Søren Saxmose Nielsen Alena Pechová Mariana Petkova Sebastien Girault Alessandro Broglia Beatriz Guerra Matteo Lorenzo Innocenti Ernesto Liébana Gloria López‐Gálvez Paola Manini Pietro Stella Luisa Peixe |
| author_sort |
EFSA Panel on Biological Hazards (BIOHAZ) |
| title |
Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed.
Part 4: β‐Lactams: amoxicillin and penicillin V |
| title_short |
Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed.
Part 4: β‐Lactams: amoxicillin and penicillin V |
| title_full |
Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed.
Part 4: β‐Lactams: amoxicillin and penicillin V |
| title_fullStr |
Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed.
Part 4: β‐Lactams: amoxicillin and penicillin V |
| title_full_unstemmed |
Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed.
Part 4: β‐Lactams: amoxicillin and penicillin V |
| title_sort |
maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed.
part 4: β‐lactams: amoxicillin and penicillin v |
| publisher |
Wiley |
| publishDate |
2021 |
| url |
https://doaj.org/article/e00518118efa4cccb61b13d5c4a3d776 |
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