Metabolic reprogramming mediates hippocampal microglial M1 polarization in response to surgical trauma causing perioperative neurocognitive disorders
Highlights Surgical trauma impaired the hippocampus-dependent contextual memory in age mice. Surgical trauma induced microglial M1 polarization and subsequent neuroinflammation. Metabolic reprogramming was crucial for regulating microglial M1 polarization in PNDs. Modulating microglial metabolism mi...
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| Autores principales: | , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
BMC
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/e0080b16969e442d8ae6534686c98b62 |
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