Metabolic reprogramming mediates hippocampal microglial M1 polarization in response to surgical trauma causing perioperative neurocognitive disorders

Highlights Surgical trauma impaired the hippocampus-dependent contextual memory in age mice. Surgical trauma induced microglial M1 polarization and subsequent neuroinflammation. Metabolic reprogramming was crucial for regulating microglial M1 polarization in PNDs. Modulating microglial metabolism mi...

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Autores principales:	Gang Luo, Xiaofeng Wang, Yongchen Cui, Yue Cao, Zhe Zhao, Junfeng Zhang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Microglial polarization Neuroinflammation Metabolic reprogramming Perioperative neurocognitive disorders (PNDs) Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/e0080b16969e442d8ae6534686c98b62
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spelling	oai:doaj.org-article:e0080b16969e442d8ae6534686c98b622021-11-14T12:38:18ZMetabolic reprogramming mediates hippocampal microglial M1 polarization in response to surgical trauma causing perioperative neurocognitive disorders10.1186/s12974-021-02318-51742-2094https://doaj.org/article/e0080b16969e442d8ae6534686c98b622021-11-01T00:00:00Zhttps://doi.org/10.1186/s12974-021-02318-5https://doaj.org/toc/1742-2094Highlights Surgical trauma impaired the hippocampus-dependent contextual memory in age mice. Surgical trauma induced microglial M1 polarization and subsequent neuroinflammation. Metabolic reprogramming was crucial for regulating microglial M1 polarization in PNDs. Modulating microglial metabolism might provide a valuable approach for treating PNDs.Gang LuoXiaofeng WangYongchen CuiYue CaoZhe ZhaoJunfeng ZhangBMCarticleMicroglial polarizationNeuroinflammationMetabolic reprogrammingPerioperative neurocognitive disorders (PNDs)Neurology. Diseases of the nervous systemRC346-429ENJournal of Neuroinflammation, Vol 18, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microglial polarization Neuroinflammation Metabolic reprogramming Perioperative neurocognitive disorders (PNDs) Neurology. Diseases of the nervous system RC346-429
spellingShingle	Microglial polarization Neuroinflammation Metabolic reprogramming Perioperative neurocognitive disorders (PNDs) Neurology. Diseases of the nervous system RC346-429 Gang Luo Xiaofeng Wang Yongchen Cui Yue Cao Zhe Zhao Junfeng Zhang Metabolic reprogramming mediates hippocampal microglial M1 polarization in response to surgical trauma causing perioperative neurocognitive disorders
description	Highlights Surgical trauma impaired the hippocampus-dependent contextual memory in age mice. Surgical trauma induced microglial M1 polarization and subsequent neuroinflammation. Metabolic reprogramming was crucial for regulating microglial M1 polarization in PNDs. Modulating microglial metabolism might provide a valuable approach for treating PNDs.
format	article
author	Gang Luo Xiaofeng Wang Yongchen Cui Yue Cao Zhe Zhao Junfeng Zhang
author_facet	Gang Luo Xiaofeng Wang Yongchen Cui Yue Cao Zhe Zhao Junfeng Zhang
author_sort	Gang Luo
title	Metabolic reprogramming mediates hippocampal microglial M1 polarization in response to surgical trauma causing perioperative neurocognitive disorders
title_short	Metabolic reprogramming mediates hippocampal microglial M1 polarization in response to surgical trauma causing perioperative neurocognitive disorders
title_full	Metabolic reprogramming mediates hippocampal microglial M1 polarization in response to surgical trauma causing perioperative neurocognitive disorders
title_fullStr	Metabolic reprogramming mediates hippocampal microglial M1 polarization in response to surgical trauma causing perioperative neurocognitive disorders
title_full_unstemmed	Metabolic reprogramming mediates hippocampal microglial M1 polarization in response to surgical trauma causing perioperative neurocognitive disorders
title_sort	metabolic reprogramming mediates hippocampal microglial m1 polarization in response to surgical trauma causing perioperative neurocognitive disorders
publisher	BMC
publishDate	2021
url	https://doaj.org/article/e0080b16969e442d8ae6534686c98b62
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Metabolic reprogramming mediates hippocampal microglial M1 polarization in response to surgical trauma causing perioperative neurocognitive disorders

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