Morphine promotes microglial activation by upregulating the EGFR/ERK signaling pathway.
Although they represent the cornerstone of analgesic therapy, opioids, such as morphine, are limited in efficacy by drug tolerance, hyperalgesia and other side effects. Activation of microglia and the consequent production of proinflammatory cytokines play a key pathogenic role in morphine tolerance...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Public Library of Science (PLoS)
2021
|
| Subjects: | |
| Online Access: | https://doaj.org/article/e01dcd0b4d3348d392cdb2905db4c659 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|