Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer’s disease

Cerebrospinal fluid (CSF) p-tau181 (tau phosphorylated at threonine 181) is an established biomarker of Alzheimer’s disease (AD) reflecting abnormal tau metabolism in the AD brain. Here the authors demonstrate that CSF p-tau217 shows better performance as an AD biomarker than p-tau181.

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Autores principales:	Shorena Janelidze, Erik Stomrud, Ruben Smith, Sebastian Palmqvist, Niklas Mattsson, David C. Airey, Nicholas K. Proctor, Xiyun Chai, Sergey Shcherbinin, John R. Sims, Gallen Triana-Baltzer, Clara Theunis, Randy Slemmon, Marc Mercken, Hartmuth Kolb, Jeffrey L. Dage, Oskar Hansson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e021f91d669745fe90cd9b4d834f6303
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spelling	oai:doaj.org-article:e021f91d669745fe90cd9b4d834f63032021-12-02T17:32:26ZCerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer’s disease10.1038/s41467-020-15436-02041-1723https://doaj.org/article/e021f91d669745fe90cd9b4d834f63032020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15436-0https://doaj.org/toc/2041-1723Cerebrospinal fluid (CSF) p-tau181 (tau phosphorylated at threonine 181) is an established biomarker of Alzheimer’s disease (AD) reflecting abnormal tau metabolism in the AD brain. Here the authors demonstrate that CSF p-tau217 shows better performance as an AD biomarker than p-tau181.Shorena JanelidzeErik StomrudRuben SmithSebastian PalmqvistNiklas MattssonDavid C. AireyNicholas K. ProctorXiyun ChaiSergey ShcherbininJohn R. SimsGallen Triana-BaltzerClara TheunisRandy SlemmonMarc MerckenHartmuth KolbJeffrey L. DageOskar HanssonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shorena Janelidze Erik Stomrud Ruben Smith Sebastian Palmqvist Niklas Mattsson David C. Airey Nicholas K. Proctor Xiyun Chai Sergey Shcherbinin John R. Sims Gallen Triana-Baltzer Clara Theunis Randy Slemmon Marc Mercken Hartmuth Kolb Jeffrey L. Dage Oskar Hansson Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer’s disease
description	Cerebrospinal fluid (CSF) p-tau181 (tau phosphorylated at threonine 181) is an established biomarker of Alzheimer’s disease (AD) reflecting abnormal tau metabolism in the AD brain. Here the authors demonstrate that CSF p-tau217 shows better performance as an AD biomarker than p-tau181.
format	article
author	Shorena Janelidze Erik Stomrud Ruben Smith Sebastian Palmqvist Niklas Mattsson David C. Airey Nicholas K. Proctor Xiyun Chai Sergey Shcherbinin John R. Sims Gallen Triana-Baltzer Clara Theunis Randy Slemmon Marc Mercken Hartmuth Kolb Jeffrey L. Dage Oskar Hansson
author_facet	Shorena Janelidze Erik Stomrud Ruben Smith Sebastian Palmqvist Niklas Mattsson David C. Airey Nicholas K. Proctor Xiyun Chai Sergey Shcherbinin John R. Sims Gallen Triana-Baltzer Clara Theunis Randy Slemmon Marc Mercken Hartmuth Kolb Jeffrey L. Dage Oskar Hansson
author_sort	Shorena Janelidze
title	Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer’s disease
title_short	Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer’s disease
title_full	Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer’s disease
title_fullStr	Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer’s disease
title_full_unstemmed	Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer’s disease
title_sort	cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of alzheimer’s disease
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e021f91d669745fe90cd9b4d834f6303
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Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer’s disease

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