TMEM16K is an interorganelle regulator of endosomal sorting
The endolysosomal pathway plays an important role in regulating protein and lipid sorting and degradation. Here, the authors show that TMEM16K, an endoplasmic reticulum lipid scramblase, forms ER-endosome contact sites where it regulates endosomal sorting.
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Nature Portfolio
2020
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oai:doaj.org-article:e026443ef1f54cb589f59433ef9e40582021-12-02T18:18:36ZTMEM16K is an interorganelle regulator of endosomal sorting10.1038/s41467-020-17016-82041-1723https://doaj.org/article/e026443ef1f54cb589f59433ef9e40582020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17016-8https://doaj.org/toc/2041-1723The endolysosomal pathway plays an important role in regulating protein and lipid sorting and degradation. Here, the authors show that TMEM16K, an endoplasmic reticulum lipid scramblase, forms ER-endosome contact sites where it regulates endosomal sorting.Maja PetkovicJuan Oses-PrietoAlma BurlingameLily Yeh JanYuh Nung JanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020) |
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Science Q Maja Petkovic Juan Oses-Prieto Alma Burlingame Lily Yeh Jan Yuh Nung Jan TMEM16K is an interorganelle regulator of endosomal sorting |
description |
The endolysosomal pathway plays an important role in regulating protein and lipid sorting and degradation. Here, the authors show that TMEM16K, an endoplasmic reticulum lipid scramblase, forms ER-endosome contact sites where it regulates endosomal sorting. |
format |
article |
author |
Maja Petkovic Juan Oses-Prieto Alma Burlingame Lily Yeh Jan Yuh Nung Jan |
author_facet |
Maja Petkovic Juan Oses-Prieto Alma Burlingame Lily Yeh Jan Yuh Nung Jan |
author_sort |
Maja Petkovic |
title |
TMEM16K is an interorganelle regulator of endosomal sorting |
title_short |
TMEM16K is an interorganelle regulator of endosomal sorting |
title_full |
TMEM16K is an interorganelle regulator of endosomal sorting |
title_fullStr |
TMEM16K is an interorganelle regulator of endosomal sorting |
title_full_unstemmed |
TMEM16K is an interorganelle regulator of endosomal sorting |
title_sort |
tmem16k is an interorganelle regulator of endosomal sorting |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/e026443ef1f54cb589f59433ef9e4058 |
work_keys_str_mv |
AT majapetkovic tmem16kisaninterorganelleregulatorofendosomalsorting AT juanosesprieto tmem16kisaninterorganelleregulatorofendosomalsorting AT almaburlingame tmem16kisaninterorganelleregulatorofendosomalsorting AT lilyyehjan tmem16kisaninterorganelleregulatorofendosomalsorting AT yuhnungjan tmem16kisaninterorganelleregulatorofendosomalsorting |
_version_ |
1718378247489585152 |