NQO1 inhibits proteasome-mediated degradation of HIF-1α

NQO1 inhibits proteasome-mediated degradation of HIF-1α

Elevated levels of the oxidoreductase NQO1 in tumours are associated with poor prognosis but how this contributes to cancer is poorly understood. Here, the authors find that NQO1 competes with PHD proteins, resulting in the stabilization of the hypoxia induced transcription factor HIF-1α.

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Detalles Bibliográficos
Autores principales: Eun-Taex Oh, Jung-whan Kim, Joon Mee Kim, Soo Jung Kim, Jae-Seon Lee, Soon-Sun Hong, Justin Goodwin, Robin J. Ruthenborg, Myung Gu Jung, Hae-June Lee, Chul-Ho Lee, Eun Sung Park, Chulhee Kim, Heon Joo Park
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/e04e3f0597364832b313a01704bb6a52
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https://doaj.org/article/e04e3f0597364832b313a01704bb6a52

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