NQO1 inhibits proteasome-mediated degradation of HIF-1α

Elevated levels of the oxidoreductase NQO1 in tumours are associated with poor prognosis but how this contributes to cancer is poorly understood. Here, the authors find that NQO1 competes with PHD proteins, resulting in the stabilization of the hypoxia induced transcription factor HIF-1α.

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Autores principales:	Eun-Taex Oh, Jung-whan Kim, Joon Mee Kim, Soo Jung Kim, Jae-Seon Lee, Soon-Sun Hong, Justin Goodwin, Robin J. Ruthenborg, Myung Gu Jung, Hae-June Lee, Chul-Ho Lee, Eun Sung Park, Chulhee Kim, Heon Joo Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e04e3f0597364832b313a01704bb6a52
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spelling	oai:doaj.org-article:e04e3f0597364832b313a01704bb6a522021-12-02T17:32:06ZNQO1 inhibits proteasome-mediated degradation of HIF-1α10.1038/ncomms135932041-1723https://doaj.org/article/e04e3f0597364832b313a01704bb6a522016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13593https://doaj.org/toc/2041-1723Elevated levels of the oxidoreductase NQO1 in tumours are associated with poor prognosis but how this contributes to cancer is poorly understood. Here, the authors find that NQO1 competes with PHD proteins, resulting in the stabilization of the hypoxia induced transcription factor HIF-1α.Eun-Taex OhJung-whan KimJoon Mee KimSoo Jung KimJae-Seon LeeSoon-Sun HongJustin GoodwinRobin J. RuthenborgMyung Gu JungHae-June LeeChul-Ho LeeEun Sung ParkChulhee KimHeon Joo ParkNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eun-Taex Oh Jung-whan Kim Joon Mee Kim Soo Jung Kim Jae-Seon Lee Soon-Sun Hong Justin Goodwin Robin J. Ruthenborg Myung Gu Jung Hae-June Lee Chul-Ho Lee Eun Sung Park Chulhee Kim Heon Joo Park NQO1 inhibits proteasome-mediated degradation of HIF-1α
description	Elevated levels of the oxidoreductase NQO1 in tumours are associated with poor prognosis but how this contributes to cancer is poorly understood. Here, the authors find that NQO1 competes with PHD proteins, resulting in the stabilization of the hypoxia induced transcription factor HIF-1α.
format	article
author	Eun-Taex Oh Jung-whan Kim Joon Mee Kim Soo Jung Kim Jae-Seon Lee Soon-Sun Hong Justin Goodwin Robin J. Ruthenborg Myung Gu Jung Hae-June Lee Chul-Ho Lee Eun Sung Park Chulhee Kim Heon Joo Park
author_facet	Eun-Taex Oh Jung-whan Kim Joon Mee Kim Soo Jung Kim Jae-Seon Lee Soon-Sun Hong Justin Goodwin Robin J. Ruthenborg Myung Gu Jung Hae-June Lee Chul-Ho Lee Eun Sung Park Chulhee Kim Heon Joo Park
author_sort	Eun-Taex Oh
title	NQO1 inhibits proteasome-mediated degradation of HIF-1α
title_short	NQO1 inhibits proteasome-mediated degradation of HIF-1α
title_full	NQO1 inhibits proteasome-mediated degradation of HIF-1α
title_fullStr	NQO1 inhibits proteasome-mediated degradation of HIF-1α
title_full_unstemmed	NQO1 inhibits proteasome-mediated degradation of HIF-1α
title_sort	nqo1 inhibits proteasome-mediated degradation of hif-1α
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/e04e3f0597364832b313a01704bb6a52
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NQO1 inhibits proteasome-mediated degradation of HIF-1α

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