NQO1 inhibits proteasome-mediated degradation of HIF-1α
Elevated levels of the oxidoreductase NQO1 in tumours are associated with poor prognosis but how this contributes to cancer is poorly understood. Here, the authors find that NQO1 competes with PHD proteins, resulting in the stabilization of the hypoxia induced transcription factor HIF-1α.
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2016
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| Subjects: | |
| Online Access: | https://doaj.org/article/e04e3f0597364832b313a01704bb6a52 |
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