Inward- and outward-facing X-ray crystal structures of homodimeric P-glycoprotein CmABCB1

P-glycoprotein, an ATP-binding cassette (ABC) transporter, extrudes a large variety of xenobiotics from the cell which protects tissues from toxins. Here authors solve a pair of X-ray structures of homodimeric P-glycoprotein and resolve structural elements proposed to participate in the mechanism of...

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Autores principales:	Atsushi Kodan, Tomohiro Yamaguchi, Toru Nakatsu, Keita Matsuoka, Yasuhisa Kimura, Kazumitsu Ueda, Hiroaki Kato
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e070bd814c674886ba6ba882b1f3a452
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spelling	oai:doaj.org-article:e070bd814c674886ba6ba882b1f3a4522021-12-02T16:58:28ZInward- and outward-facing X-ray crystal structures of homodimeric P-glycoprotein CmABCB110.1038/s41467-018-08007-x2041-1723https://doaj.org/article/e070bd814c674886ba6ba882b1f3a4522019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08007-xhttps://doaj.org/toc/2041-1723P-glycoprotein, an ATP-binding cassette (ABC) transporter, extrudes a large variety of xenobiotics from the cell which protects tissues from toxins. Here authors solve a pair of X-ray structures of homodimeric P-glycoprotein and resolve structural elements proposed to participate in the mechanism of the transporter.Atsushi KodanTomohiro YamaguchiToru NakatsuKeita MatsuokaYasuhisa KimuraKazumitsu UedaHiroaki KatoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Atsushi Kodan Tomohiro Yamaguchi Toru Nakatsu Keita Matsuoka Yasuhisa Kimura Kazumitsu Ueda Hiroaki Kato Inward- and outward-facing X-ray crystal structures of homodimeric P-glycoprotein CmABCB1
description	P-glycoprotein, an ATP-binding cassette (ABC) transporter, extrudes a large variety of xenobiotics from the cell which protects tissues from toxins. Here authors solve a pair of X-ray structures of homodimeric P-glycoprotein and resolve structural elements proposed to participate in the mechanism of the transporter.
format	article
author	Atsushi Kodan Tomohiro Yamaguchi Toru Nakatsu Keita Matsuoka Yasuhisa Kimura Kazumitsu Ueda Hiroaki Kato
author_facet	Atsushi Kodan Tomohiro Yamaguchi Toru Nakatsu Keita Matsuoka Yasuhisa Kimura Kazumitsu Ueda Hiroaki Kato
author_sort	Atsushi Kodan
title	Inward- and outward-facing X-ray crystal structures of homodimeric P-glycoprotein CmABCB1
title_short	Inward- and outward-facing X-ray crystal structures of homodimeric P-glycoprotein CmABCB1
title_full	Inward- and outward-facing X-ray crystal structures of homodimeric P-glycoprotein CmABCB1
title_fullStr	Inward- and outward-facing X-ray crystal structures of homodimeric P-glycoprotein CmABCB1
title_full_unstemmed	Inward- and outward-facing X-ray crystal structures of homodimeric P-glycoprotein CmABCB1
title_sort	inward- and outward-facing x-ray crystal structures of homodimeric p-glycoprotein cmabcb1
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e070bd814c674886ba6ba882b1f3a452
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Inward- and outward-facing X-ray crystal structures of homodimeric P-glycoprotein CmABCB1

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