Dynamics of the major histocompatibility complex class I processing and presentation pathway in the course of malaria parasite development in human hepatocytes: implications for vaccine development.

Dynamics of the major histocompatibility complex class I processing and presentation pathway in the course of malaria parasite development in human hepatocytes: implications for vaccine development.

Control of parasite replication exerted by MHC class I restricted CD8+ T-cells in the liver is critical for vaccination-induced protection against malaria. While many intracellular pathogens subvert the MHC class I presentation machinery, its functionality in the course of malaria replication in hep...

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Bibliographic Details
Main Authors: Jinxia Ma, Stefanie Trop, Samantha Baer, Elian Rakhmanaliev, Zita Arany, Peter Dumoulin, Hao Zhang, Julia Romano, Isabelle Coppens, Victor Levitsky, Jelena Levitskaya
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/e09d1355f11a4c29833e9b05d5fca36d
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