The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery

QR Code

The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery

The SARS-CoV-2 papain-like protease (PLpro) is of interest as a drug target. Here, the authors identify GRL0617 as a PPI (protein–protein interaction) inhibitor of SARS-CoV-2 PLpro that inhibits its deISGylating activity and present the mechanism of action of the compound through the GRL0617-bound P...

Description complète

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Ziyang Fu, Bin Huang, Jinle Tang, Shuyan Liu, Ming Liu, Yuxin Ye, Zhihong Liu, Yuxian Xiong, Wenning Zhu, Dan Cao, Jihui Li, Xiaogang Niu, Huan Zhou, Yong Juan Zhao, Guoliang Zhang, Hao Huang
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/e0b510d04f0846f9afbec3f3b04bc27e
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires

SpotOn: High Accuracy Identification of Protein-Protein Interface Hot-Spots
par: Irina S. Moreira, et autres
Publié: (2017)

Structural hot spots for the solubility of globular proteins
par: Ashok Ganesan, et autres
Publié: (2016)

Concentration of strontium-90 at selected hot spots in Japan.
par: Georg Steinhauser, et autres
Publié: (2013)

GRL-0920, an Indole Chloropyridinyl Ester, Completely Blocks SARS-CoV-2 Infection
par: Shin-ichiro Hattori, et autres
Publié: (2020)

Investing in Networking Competences or Establishing in Hot Spots?: The Innovation Dilemna
par: Hussler,Caroline, et autres
Publié: (2009)

Research Hot Spots and Trends on Melatonin From 2000 to 2019
par: Yan Meng, et autres
Publié: (2021)

A rapid density method for taxi passengers hot spot recognition and visualization based on DBSCAN+
par: Zihe Huang, et autres
Publié: (2021)

Tea plantations and their importance as host plants and hot spots for epiphytic cryptogams
par: Grzegorz J. Wolski, et autres
Publié: (2021)

Maternal HIV and syphilis are not syndemic in Brazil: Hot spot analysis of the two epidemics.
par: Mary Catherine Cambou, et autres
Publié: (2021)

Mapping ecoacoustic hot spots and moments of biodiversity to inform conservation and urban planning
par: Briana Holgate, et autres
Publié: (2021)

In Situ Non-Destructive Temporal Measurements of the Rhizosphere Microbiome ‘Hot-Spots’ Using Metaproteomics
par: Richard Allen White, et autres
Publié: (2021)

Spatial fine-mapping for gene-by-environment effects identifies risk hot spots for schizophrenia
par: Chun Chieh Fan, et autres
Publié: (2018)

SV-HotSpot: detection and visualization of hotspots targeted by structural variants associated with gene expression
par: Abdallah M. Eteleeb, et autres
Publié: (2020)

"Hot-spotting" to improve vaccine allocation by harnessing digital contact tracing technology: An application of percolation theory.
par: Mark D Penney, et autres
Publié: (2021)

Genome-wide identification of meiotic recombination hot spots detected by SLAF in peanut (Arachis hypogaea L.)
par: Xiaohua Wang, et autres
Publié: (2020)

Microtubules regulate pancreatic β-cell heterogeneity via spatiotemporal control of insulin secretion hot spots
par: Kathryn P Trogden, et autres
Publié: (2021)

Plant resource uses and losses in a small maroon community in a Colombian Pacific hot spot
par: Danielly Vasconcelos Travassos de Lima, et autres
Publié: (2021)

Optimum protein requirement of juvenile orange-spotted grouper (Epinephelus coioides)
par: Xiaobo Yan, et autres
Publié: (2021)

An Autocrine Proliferation Repressor Regulates <italic toggle="yes">Dictyostelium discoideum</italic> Proliferation and Chemorepulsion Using the G Protein-Coupled Receptor GrlH
par: Yu Tang, et autres
Publié: (2018)

Substrate-binding destabilizes the hydrophobic cluster to relieve the autoinhibition of bacterial ubiquitin ligase IpaH9.8
par: Yuxin Ye, et autres
Publié: (2020)

Cellular imaging by targeted assembly of hot-spot SERS and photoacoustic nanoprobes using split-fluorescent protein scaffolds
par: Tuğba Köker, et autres
Publié: (2018)

The European Forest Condition Monitor: Using Remotely Sensed Forest Greenness to Identify Hot Spots of Forest Decline
par: Allan Buras, et autres
Publié: (2021)

Author Correction: Optimum protein requirement of juvenile orange-spotted grouper (Epinephelus coioides)
par: Xiaobo Yan, et autres
Publié: (2021)

Identification of antigenic domains and peptides from VP15 of white spot syndrome virus and their antiviral effects in Marsupenaeus japonicus
par: Jirayu Boonyakida, et autres
Publié: (2021)

Accelerating vaccine trial conduct in a pandemic with a hot spot‐based inclusion strategy using trial and epidemic simulation
par: Johan L. van derPlas, et autres
Publié: (2021)

Marine Sponges as <italic toggle="yes">Chloroflexi</italic> Hot Spots: Genomic Insights and High-Resolution Visualization of an Abundant and Diverse Symbiotic Clade
par: Kristina Bayer, et autres
Publié: (2018)

Prediction of hot metal temperature based on data mining
par: Jun Zhao, et autres
Publié: (2021)

Long-lived hot-carrier light emission and large blue shift in formamidinium tin triiodide perovskites
par: Hong-Hua Fang, et autres
Publié: (2018)

Antiviral Drug Discovery To Address the COVID-19 Pandemic
par: Douglas D. Richman
Publié: (2020)

ISGylation in Innate Antiviral Immunity and Pathogen Defense Responses: A Review
par: Mengdi Zhang, et autres
Publié: (2021)

SARS‐CoV‐2–host proteome interactions for antiviral drug discovery
par: Xiaonan Liu, et autres
Publié: (2021)

Quick evaluation of hot air ageing resistance for natural rubber
par: WU Ling-ling1, WANG Xue-fei1, WANG Chang-ying2, LIU Quan1, HUANG Liang-ping1, YU Hai-wen1
Publié: (2021)

Discovery of New Ginsenol-Like Compounds with High Antiviral Activity
par: Aleksandrina S. Volobueva, et autres
Publié: (2021)

Facilitating Antiviral Drug Discovery Using Genetic and Evolutionary Knowledge
par: Xuan Xu, et autres
Publié: (2021)

Moreno Carranco, M. (2015), Geografías en construcción: el megaproyecto de Santa Fe en la Ciudad de México, Universidad Autónoma Metropolitana-Cuajimalpa, México, 280 pp., ISBN 978-607-28-0617-7
par: Consuelo Córdoba Flores
Publié: (2017)

Preparation of MnO2 modified magnetic graphitic carbon nitride composite and its adsorption toward Pb(II) in waste water
par: Wenning Xia, et autres
Publié: (2021)

Investigation of large area sheet forming with laser shocking spot by spot
par: Xingquan Zhang, et autres
Publié: (2021)

Antiviral research
Publié: (1981)

Comparative Genomics and Integrated Network Approach Unveiled Undirected Phylogeny Patterns, Co-mutational Hot Spots, Functional Cross Talk, and Regulatory Interactions in SARS-CoV-2
par: Vipin Gupta, et autres
Publié: (2021)

Target Discovery for Host-Directed Antiviral Therapies: Application of Proteomics Approaches
par: Merve Cakir, et autres
Publié: (2021)