Intermolecular biparatopic trapping of ErbB2 prevents compensatory activation of PI3K/AKT via RAS–p110 crosstalk

Targeted therapy of ErbB2-dependent tumours often provokes an adaptive response leading to reactivation of the PI3K/AKT pathway. Here the authors identify an ErbB3-independent compensatory mechanism comprising Ras/PI3K activation directly by ErbB2, and develop biparatopic panErbB inhibitors to block...

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Autores principales:	Rastislav Tamaskovic, Martin Schwill, Gabriela Nagy-Davidescu, Christian Jost, Dagmar C. Schaefer, Wouter P. R. Verdurmen, Jonas V. Schaefer, Annemarie Honegger, Andreas Plückthun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e0be6e1f3bd245178be008000c067b2e
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spelling	oai:doaj.org-article:e0be6e1f3bd245178be008000c067b2e2021-12-02T15:34:30ZIntermolecular biparatopic trapping of ErbB2 prevents compensatory activation of PI3K/AKT via RAS–p110 crosstalk10.1038/ncomms116722041-1723https://doaj.org/article/e0be6e1f3bd245178be008000c067b2e2016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11672https://doaj.org/toc/2041-1723Targeted therapy of ErbB2-dependent tumours often provokes an adaptive response leading to reactivation of the PI3K/AKT pathway. Here the authors identify an ErbB3-independent compensatory mechanism comprising Ras/PI3K activation directly by ErbB2, and develop biparatopic panErbB inhibitors to block this mode of resistance.Rastislav TamaskovicMartin SchwillGabriela Nagy-DavidescuChristian JostDagmar C. SchaeferWouter P. R. VerdurmenJonas V. SchaeferAnnemarie HoneggerAndreas PlückthunNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rastislav Tamaskovic Martin Schwill Gabriela Nagy-Davidescu Christian Jost Dagmar C. Schaefer Wouter P. R. Verdurmen Jonas V. Schaefer Annemarie Honegger Andreas Plückthun Intermolecular biparatopic trapping of ErbB2 prevents compensatory activation of PI3K/AKT via RAS–p110 crosstalk
description	Targeted therapy of ErbB2-dependent tumours often provokes an adaptive response leading to reactivation of the PI3K/AKT pathway. Here the authors identify an ErbB3-independent compensatory mechanism comprising Ras/PI3K activation directly by ErbB2, and develop biparatopic panErbB inhibitors to block this mode of resistance.
format	article
author	Rastislav Tamaskovic Martin Schwill Gabriela Nagy-Davidescu Christian Jost Dagmar C. Schaefer Wouter P. R. Verdurmen Jonas V. Schaefer Annemarie Honegger Andreas Plückthun
author_facet	Rastislav Tamaskovic Martin Schwill Gabriela Nagy-Davidescu Christian Jost Dagmar C. Schaefer Wouter P. R. Verdurmen Jonas V. Schaefer Annemarie Honegger Andreas Plückthun
author_sort	Rastislav Tamaskovic
title	Intermolecular biparatopic trapping of ErbB2 prevents compensatory activation of PI3K/AKT via RAS–p110 crosstalk
title_short	Intermolecular biparatopic trapping of ErbB2 prevents compensatory activation of PI3K/AKT via RAS–p110 crosstalk
title_full	Intermolecular biparatopic trapping of ErbB2 prevents compensatory activation of PI3K/AKT via RAS–p110 crosstalk
title_fullStr	Intermolecular biparatopic trapping of ErbB2 prevents compensatory activation of PI3K/AKT via RAS–p110 crosstalk
title_full_unstemmed	Intermolecular biparatopic trapping of ErbB2 prevents compensatory activation of PI3K/AKT via RAS–p110 crosstalk
title_sort	intermolecular biparatopic trapping of erbb2 prevents compensatory activation of pi3k/akt via ras–p110 crosstalk
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/e0be6e1f3bd245178be008000c067b2e
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Intermolecular biparatopic trapping of ErbB2 prevents compensatory activation of PI3K/AKT via RAS–p110 crosstalk

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