ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens

The generation of protective secretory IgA is a desired outcome of oral vaccination. Here, the authors show that the depletion of intestinal ATP significantly improves the production and response of high-affinity IgA against both live and inactivated oral vaccines.

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Autores principales:	Michele Proietti, Lisa Perruzza, Daniela Scribano, Giovanni Pellegrini, Rocco D’Antuono, Francesco Strati, Marco Raffaelli, Santiago F. Gonzalez, Marcus Thelen, Wolf-Dietrich Hardt, Emma Slack, Mauro Nicoletti, Fabio Grassi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e0e24831b05347f7a1b912b1db0a67fd
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spelling	oai:doaj.org-article:e0e24831b05347f7a1b912b1db0a67fd2021-12-02T16:58:14ZATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens10.1038/s41467-018-08156-z2041-1723https://doaj.org/article/e0e24831b05347f7a1b912b1db0a67fd2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08156-zhttps://doaj.org/toc/2041-1723The generation of protective secretory IgA is a desired outcome of oral vaccination. Here, the authors show that the depletion of intestinal ATP significantly improves the production and response of high-affinity IgA against both live and inactivated oral vaccines.Michele ProiettiLisa PerruzzaDaniela ScribanoGiovanni PellegriniRocco D’AntuonoFrancesco StratiMarco RaffaelliSantiago F. GonzalezMarcus ThelenWolf-Dietrich HardtEmma SlackMauro NicolettiFabio GrassiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michele Proietti Lisa Perruzza Daniela Scribano Giovanni Pellegrini Rocco D’Antuono Francesco Strati Marco Raffaelli Santiago F. Gonzalez Marcus Thelen Wolf-Dietrich Hardt Emma Slack Mauro Nicoletti Fabio Grassi ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens
description	The generation of protective secretory IgA is a desired outcome of oral vaccination. Here, the authors show that the depletion of intestinal ATP significantly improves the production and response of high-affinity IgA against both live and inactivated oral vaccines.
format	article
author	Michele Proietti Lisa Perruzza Daniela Scribano Giovanni Pellegrini Rocco D’Antuono Francesco Strati Marco Raffaelli Santiago F. Gonzalez Marcus Thelen Wolf-Dietrich Hardt Emma Slack Mauro Nicoletti Fabio Grassi
author_facet	Michele Proietti Lisa Perruzza Daniela Scribano Giovanni Pellegrini Rocco D’Antuono Francesco Strati Marco Raffaelli Santiago F. Gonzalez Marcus Thelen Wolf-Dietrich Hardt Emma Slack Mauro Nicoletti Fabio Grassi
author_sort	Michele Proietti
title	ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens
title_short	ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens
title_full	ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens
title_fullStr	ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens
title_full_unstemmed	ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens
title_sort	atp released by intestinal bacteria limits the generation of protective iga against enteropathogens
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e0e24831b05347f7a1b912b1db0a67fd
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ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens

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