Synthesis of chiral α-trifluoromethyl alcohols and ethers via enantioselective Hiyama cross-couplings of bisfunctionalized electrophiles
Compounds containing stereocenters bearing -CF3 groups, especially in proximity of heteroatoms, are of great interest for drug and agrochemicals development. Here, the authors report a nickel-catalyzed Hiyama cross-coupling methodology for the asymmetric synthesis of valuable alpha-trifluoromethyl a...
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| Auteurs principaux: | , |
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| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2018
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| Accès en ligne: | https://doaj.org/article/e0f97575a331498185d58aa843393fed |
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