Synthesis of chiral α-trifluoromethyl alcohols and ethers via enantioselective Hiyama cross-couplings of bisfunctionalized electrophiles

Compounds containing stereocenters bearing -CF3 groups, especially in proximity of heteroatoms, are of great interest for drug and agrochemicals development. Here, the authors report a nickel-catalyzed Hiyama cross-coupling methodology for the asymmetric synthesis of valuable alpha-trifluoromethyl a...

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Auteurs principaux:	Andrii Varenikov, Mark Gandelman
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/e0f97575a331498185d58aa843393fed
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spelling	oai:doaj.org-article:e0f97575a331498185d58aa843393fed2021-12-02T16:49:39ZSynthesis of chiral α-trifluoromethyl alcohols and ethers via enantioselective Hiyama cross-couplings of bisfunctionalized electrophiles10.1038/s41467-018-05946-32041-1723https://doaj.org/article/e0f97575a331498185d58aa843393fed2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05946-3https://doaj.org/toc/2041-1723Compounds containing stereocenters bearing -CF3 groups, especially in proximity of heteroatoms, are of great interest for drug and agrochemicals development. Here, the authors report a nickel-catalyzed Hiyama cross-coupling methodology for the asymmetric synthesis of valuable alpha-trifluoromethyl alcohols and ethers.Andrii VarenikovMark GandelmanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andrii Varenikov Mark Gandelman Synthesis of chiral α-trifluoromethyl alcohols and ethers via enantioselective Hiyama cross-couplings of bisfunctionalized electrophiles
description	Compounds containing stereocenters bearing -CF3 groups, especially in proximity of heteroatoms, are of great interest for drug and agrochemicals development. Here, the authors report a nickel-catalyzed Hiyama cross-coupling methodology for the asymmetric synthesis of valuable alpha-trifluoromethyl alcohols and ethers.
format	article
author	Andrii Varenikov Mark Gandelman
author_facet	Andrii Varenikov Mark Gandelman
author_sort	Andrii Varenikov
title	Synthesis of chiral α-trifluoromethyl alcohols and ethers via enantioselective Hiyama cross-couplings of bisfunctionalized electrophiles
title_short	Synthesis of chiral α-trifluoromethyl alcohols and ethers via enantioselective Hiyama cross-couplings of bisfunctionalized electrophiles
title_full	Synthesis of chiral α-trifluoromethyl alcohols and ethers via enantioselective Hiyama cross-couplings of bisfunctionalized electrophiles
title_fullStr	Synthesis of chiral α-trifluoromethyl alcohols and ethers via enantioselective Hiyama cross-couplings of bisfunctionalized electrophiles
title_full_unstemmed	Synthesis of chiral α-trifluoromethyl alcohols and ethers via enantioselective Hiyama cross-couplings of bisfunctionalized electrophiles
title_sort	synthesis of chiral α-trifluoromethyl alcohols and ethers via enantioselective hiyama cross-couplings of bisfunctionalized electrophiles
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e0f97575a331498185d58aa843393fed
work_keys_str_mv	AT andriivarenikov synthesisofchiralatrifluoromethylalcoholsandethersviaenantioselectivehiyamacrosscouplingsofbisfunctionalizedelectrophiles AT markgandelman synthesisofchiralatrifluoromethylalcoholsandethersviaenantioselectivehiyamacrosscouplingsofbisfunctionalizedelectrophiles
_version_	1718383307846057984

Synthesis of chiral α-trifluoromethyl alcohols and ethers via enantioselective Hiyama cross-couplings of bisfunctionalized electrophiles

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