Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders

Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders

How neurodevelopmental disorder-associated risk genes are translated into spatially patterned brain vulnerabilities is unclear. Here, the authors show that disorder-specific patterns of neuroanatomical changes are aligned to brain expression maps of disease risk genes in healthy subjects.

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Auteurs principaux: Jakob Seidlitz, Ajay Nadig, Siyuan Liu, Richard A. I. Bethlehem, Petra E. Vértes, Sarah E. Morgan, František Váša, Rafael Romero-Garcia, François M. Lalonde, Liv S. Clasen, Jonathan D. Blumenthal, Casey Paquola, Boris Bernhardt, Konrad Wagstyl, Damon Polioudakis, Luis de la Torre-Ubieta, Daniel H. Geschwind, Joan C. Han, Nancy R. Lee, Declan G. Murphy, Edward T. Bullmore, Armin Raznahan
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Science
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Accès en ligne:https://doaj.org/article/e108dc74dcb44e0eb2823e27b1ef55dc
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Internet

https://doaj.org/article/e108dc74dcb44e0eb2823e27b1ef55dc

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