Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders

How neurodevelopmental disorder-associated risk genes are translated into spatially patterned brain vulnerabilities is unclear. Here, the authors show that disorder-specific patterns of neuroanatomical changes are aligned to brain expression maps of disease risk genes in healthy subjects.

Guardado en:
Detalles Bibliográficos
Autores principales: Jakob Seidlitz, Ajay Nadig, Siyuan Liu, Richard A. I. Bethlehem, Petra E. Vértes, Sarah E. Morgan, František Váša, Rafael Romero-Garcia, François M. Lalonde, Liv S. Clasen, Jonathan D. Blumenthal, Casey Paquola, Boris Bernhardt, Konrad Wagstyl, Damon Polioudakis, Luis de la Torre-Ubieta, Daniel H. Geschwind, Joan C. Han, Nancy R. Lee, Declan G. Murphy, Edward T. Bullmore, Armin Raznahan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Q
Acceso en línea:https://doaj.org/article/e108dc74dcb44e0eb2823e27b1ef55dc
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:e108dc74dcb44e0eb2823e27b1ef55dc
record_format dspace
spelling oai:doaj.org-article:e108dc74dcb44e0eb2823e27b1ef55dc2021-12-02T16:10:47ZTranscriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders10.1038/s41467-020-17051-52041-1723https://doaj.org/article/e108dc74dcb44e0eb2823e27b1ef55dc2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17051-5https://doaj.org/toc/2041-1723How neurodevelopmental disorder-associated risk genes are translated into spatially patterned brain vulnerabilities is unclear. Here, the authors show that disorder-specific patterns of neuroanatomical changes are aligned to brain expression maps of disease risk genes in healthy subjects.Jakob SeidlitzAjay NadigSiyuan LiuRichard A. I. BethlehemPetra E. VértesSarah E. MorganFrantišek VášaRafael Romero-GarciaFrançois M. LalondeLiv S. ClasenJonathan D. BlumenthalCasey PaquolaBoris BernhardtKonrad WagstylDamon PolioudakisLuis de la Torre-UbietaDaniel H. GeschwindJoan C. HanNancy R. LeeDeclan G. MurphyEdward T. BullmoreArmin RaznahanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jakob Seidlitz
Ajay Nadig
Siyuan Liu
Richard A. I. Bethlehem
Petra E. Vértes
Sarah E. Morgan
František Váša
Rafael Romero-Garcia
François M. Lalonde
Liv S. Clasen
Jonathan D. Blumenthal
Casey Paquola
Boris Bernhardt
Konrad Wagstyl
Damon Polioudakis
Luis de la Torre-Ubieta
Daniel H. Geschwind
Joan C. Han
Nancy R. Lee
Declan G. Murphy
Edward T. Bullmore
Armin Raznahan
Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders
description How neurodevelopmental disorder-associated risk genes are translated into spatially patterned brain vulnerabilities is unclear. Here, the authors show that disorder-specific patterns of neuroanatomical changes are aligned to brain expression maps of disease risk genes in healthy subjects.
format article
author Jakob Seidlitz
Ajay Nadig
Siyuan Liu
Richard A. I. Bethlehem
Petra E. Vértes
Sarah E. Morgan
František Váša
Rafael Romero-Garcia
François M. Lalonde
Liv S. Clasen
Jonathan D. Blumenthal
Casey Paquola
Boris Bernhardt
Konrad Wagstyl
Damon Polioudakis
Luis de la Torre-Ubieta
Daniel H. Geschwind
Joan C. Han
Nancy R. Lee
Declan G. Murphy
Edward T. Bullmore
Armin Raznahan
author_facet Jakob Seidlitz
Ajay Nadig
Siyuan Liu
Richard A. I. Bethlehem
Petra E. Vértes
Sarah E. Morgan
František Váša
Rafael Romero-Garcia
François M. Lalonde
Liv S. Clasen
Jonathan D. Blumenthal
Casey Paquola
Boris Bernhardt
Konrad Wagstyl
Damon Polioudakis
Luis de la Torre-Ubieta
Daniel H. Geschwind
Joan C. Han
Nancy R. Lee
Declan G. Murphy
Edward T. Bullmore
Armin Raznahan
author_sort Jakob Seidlitz
title Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders
title_short Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders
title_full Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders
title_fullStr Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders
title_full_unstemmed Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders
title_sort transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/e108dc74dcb44e0eb2823e27b1ef55dc
work_keys_str_mv AT jakobseidlitz transcriptomicandcellulardecodingofregionalbrainvulnerabilitytoneurogeneticdisorders
AT ajaynadig transcriptomicandcellulardecodingofregionalbrainvulnerabilitytoneurogeneticdisorders
AT siyuanliu transcriptomicandcellulardecodingofregionalbrainvulnerabilitytoneurogeneticdisorders
AT richardaibethlehem transcriptomicandcellulardecodingofregionalbrainvulnerabilitytoneurogeneticdisorders
AT petraevertes transcriptomicandcellulardecodingofregionalbrainvulnerabilitytoneurogeneticdisorders
AT sarahemorgan transcriptomicandcellulardecodingofregionalbrainvulnerabilitytoneurogeneticdisorders
AT frantisekvasa transcriptomicandcellulardecodingofregionalbrainvulnerabilitytoneurogeneticdisorders
AT rafaelromerogarcia transcriptomicandcellulardecodingofregionalbrainvulnerabilitytoneurogeneticdisorders
AT francoismlalonde transcriptomicandcellulardecodingofregionalbrainvulnerabilitytoneurogeneticdisorders
AT livsclasen transcriptomicandcellulardecodingofregionalbrainvulnerabilitytoneurogeneticdisorders
AT jonathandblumenthal transcriptomicandcellulardecodingofregionalbrainvulnerabilitytoneurogeneticdisorders
AT caseypaquola transcriptomicandcellulardecodingofregionalbrainvulnerabilitytoneurogeneticdisorders
AT borisbernhardt transcriptomicandcellulardecodingofregionalbrainvulnerabilitytoneurogeneticdisorders
AT konradwagstyl transcriptomicandcellulardecodingofregionalbrainvulnerabilitytoneurogeneticdisorders
AT damonpolioudakis transcriptomicandcellulardecodingofregionalbrainvulnerabilitytoneurogeneticdisorders
AT luisdelatorreubieta transcriptomicandcellulardecodingofregionalbrainvulnerabilitytoneurogeneticdisorders
AT danielhgeschwind transcriptomicandcellulardecodingofregionalbrainvulnerabilitytoneurogeneticdisorders
AT joanchan transcriptomicandcellulardecodingofregionalbrainvulnerabilitytoneurogeneticdisorders
AT nancyrlee transcriptomicandcellulardecodingofregionalbrainvulnerabilitytoneurogeneticdisorders
AT declangmurphy transcriptomicandcellulardecodingofregionalbrainvulnerabilitytoneurogeneticdisorders
AT edwardtbullmore transcriptomicandcellulardecodingofregionalbrainvulnerabilitytoneurogeneticdisorders
AT arminraznahan transcriptomicandcellulardecodingofregionalbrainvulnerabilitytoneurogeneticdisorders
_version_ 1718384442005782528