Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders

How neurodevelopmental disorder-associated risk genes are translated into spatially patterned brain vulnerabilities is unclear. Here, the authors show that disorder-specific patterns of neuroanatomical changes are aligned to brain expression maps of disease risk genes in healthy subjects.

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Auteurs principaux:	Jakob Seidlitz, Ajay Nadig, Siyuan Liu, Richard A. I. Bethlehem, Petra E. Vértes, Sarah E. Morgan, František Váša, Rafael Romero-Garcia, François M. Lalonde, Liv S. Clasen, Jonathan D. Blumenthal, Casey Paquola, Boris Bernhardt, Konrad Wagstyl, Damon Polioudakis, Luis de la Torre-Ubieta, Daniel H. Geschwind, Joan C. Han, Nancy R. Lee, Declan G. Murphy, Edward T. Bullmore, Armin Raznahan
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/e108dc74dcb44e0eb2823e27b1ef55dc
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spelling	oai:doaj.org-article:e108dc74dcb44e0eb2823e27b1ef55dc2021-12-02T16:10:47ZTranscriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders10.1038/s41467-020-17051-52041-1723https://doaj.org/article/e108dc74dcb44e0eb2823e27b1ef55dc2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17051-5https://doaj.org/toc/2041-1723How neurodevelopmental disorder-associated risk genes are translated into spatially patterned brain vulnerabilities is unclear. Here, the authors show that disorder-specific patterns of neuroanatomical changes are aligned to brain expression maps of disease risk genes in healthy subjects.Jakob SeidlitzAjay NadigSiyuan LiuRichard A. I. BethlehemPetra E. VértesSarah E. MorganFrantišek VášaRafael Romero-GarciaFrançois M. LalondeLiv S. ClasenJonathan D. BlumenthalCasey PaquolaBoris BernhardtKonrad WagstylDamon PolioudakisLuis de la Torre-UbietaDaniel H. GeschwindJoan C. HanNancy R. LeeDeclan G. MurphyEdward T. BullmoreArmin RaznahanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jakob Seidlitz Ajay Nadig Siyuan Liu Richard A. I. Bethlehem Petra E. Vértes Sarah E. Morgan František Váša Rafael Romero-Garcia François M. Lalonde Liv S. Clasen Jonathan D. Blumenthal Casey Paquola Boris Bernhardt Konrad Wagstyl Damon Polioudakis Luis de la Torre-Ubieta Daniel H. Geschwind Joan C. Han Nancy R. Lee Declan G. Murphy Edward T. Bullmore Armin Raznahan Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders
description	How neurodevelopmental disorder-associated risk genes are translated into spatially patterned brain vulnerabilities is unclear. Here, the authors show that disorder-specific patterns of neuroanatomical changes are aligned to brain expression maps of disease risk genes in healthy subjects.
format	article
author	Jakob Seidlitz Ajay Nadig Siyuan Liu Richard A. I. Bethlehem Petra E. Vértes Sarah E. Morgan František Váša Rafael Romero-Garcia François M. Lalonde Liv S. Clasen Jonathan D. Blumenthal Casey Paquola Boris Bernhardt Konrad Wagstyl Damon Polioudakis Luis de la Torre-Ubieta Daniel H. Geschwind Joan C. Han Nancy R. Lee Declan G. Murphy Edward T. Bullmore Armin Raznahan
author_facet	Jakob Seidlitz Ajay Nadig Siyuan Liu Richard A. I. Bethlehem Petra E. Vértes Sarah E. Morgan František Váša Rafael Romero-Garcia François M. Lalonde Liv S. Clasen Jonathan D. Blumenthal Casey Paquola Boris Bernhardt Konrad Wagstyl Damon Polioudakis Luis de la Torre-Ubieta Daniel H. Geschwind Joan C. Han Nancy R. Lee Declan G. Murphy Edward T. Bullmore Armin Raznahan
author_sort	Jakob Seidlitz
title	Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders
title_short	Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders
title_full	Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders
title_fullStr	Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders
title_full_unstemmed	Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders
title_sort	transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e108dc74dcb44e0eb2823e27b1ef55dc
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Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders

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