Cell–cell fusion of mesenchymal cells with distinct differentiations triggers genomic and transcriptomic remodelling toward tumour aggressiveness
Abstract Cell–cell fusion is a physiological process that is hijacked during oncogenesis and promotes tumour evolution. The main known impact of cell fusion is to promote the formation of metastatic hybrid cells following fusion between mobile leucocytes and proliferating tumour cells. We show here...
Saved in:
Main Authors: | Lucile Delespaul, Caroline Gélabert, Tom Lesluyes, Sophie Le Guellec, Gaëlle Pérot, Laura Leroy, Jessica Baud, Candice Merle, Lydia Lartigue, Frédéric Chibon |
---|---|
Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2020
|
Subjects: | |
Online Access: | https://doaj.org/article/e15b144579b1483494041a6ae5a87f2c |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
The CINSARC signature as a prognostic marker for clinical outcome in multiple neoplasms
by: Tom Lesluyes, et al.
Published: (2017) -
Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness
by: Alexandra Avgustinova, et al.
Published: (2016) -
Germinal GLT8D1, GATAD2A and SLC25A39 mutations in a patient with a glomangiopericytal tumor and five different sarcomas over a 10-year period
by: Arnaud Beddok, et al.
Published: (2021) -
Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination
by: Caroline P. Le, et al.
Published: (2016) -
Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis
by: Raymond K. H. Yip, et al.
Published: (2021)